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Olanzapine

Olanzapine

Product ID O4400
Cas No. 132539-06-1
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $102.00 In stock
250 mg $204.30 In stock
1 g $612.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Olanzapine is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, panic disorder, anxiety, and Tourette’s syndrome. Olanzapine acts as an antagonist or inverse agonist at D1-4 receptors, 5-HT1A/2/3/6/7 receptors, muscarinic acetylcholine receptors (M1-5 mAChRs), α1/2-adrenergic receptors, and histamine receptors. This compound also activates AMPK in the hypothalamus, increasing blood glucose levels. Olanzapine exhibits neuroprotective activity, upregulating BDNF gene transcription and modulating PGE2 and arachidonic acid levels during chronic use.

Product Info

Cas No.

132539-06-1

Purity

≥99%

Formula

C17H20N4S

Formula Wt.

312.43

Chemical Name

2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

IUPAC Name

2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine

Solubility

1mg/ml in ethanol, 16mg/ml in DMSO, and 20 mg/ml in DMF, sparingly soluble in aqueous buffers

Appearance

Yellow crystal powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

O4400 MSDS PDF

Info Sheet

O4400 Info Sheet PDF

References

Ikegami M, Ikeda H, Ishikawa Y, et al. Olanzapine induces glucose intolerance through the activation of AMPK in the mouse hypothalamus. Eur J Pharmacol. 2013 Aug 22. [Epub ahead of print]. PMID: 23973646.

Cheon Y, Park JY, Modi HR, et al. Chronic olanzapine treatment decreases arachidonic acid turnover and prostaglandin E₂ concentration in rat brain. J Neurochem. 2011 Oct;119(2):364-76. PMID: 21812779.

Lee JG, Cho HY, Park SW, et al. Effects of olanzapine on brain-derived neurotrophic factor gene promoter activity in SH-SY5Y neuroblastoma cells. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1001-6. PMID: 20546816.

Sepede G, De Berardis D, Gambi F, et al. Olanzapine augmentation in treatment-resistant panic disorder: a 12-week, fixed-dose, open-label trial. J Clin Psychopharmacol. 2006 Feb;26(1):45-9. PMID: 16475705.

Bymaster FP, Calligaro DO, Falcone JF, et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology. 1996 Feb;14(2):87-96. PMID: 8822531.

Custom Order

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