LKT Labs

Biochemicals for Life Science Research

Oleuropein

Oleuropein

Product ID O446185
Cas No. 32619-42-4
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $53.00 In stock
25 mg $98.00 In stock
100 mg $278.00 In stock
250 mg $526.00 Please Inquire
Bulk Quote

Quicklinks

Description

Oleuropein is a bioactive compound found in all parts of the olive tree. Oleuropein has been shown to reduce intracellular ROS generation, inhibit apoptosis, stabilize mitochondrial membrane potential, modulate apoptotic proteins, and increase phosphorylation of Akt and ERK1/2 in neonatal rat cardiomyocytes subjected to simulation of ischemia/reperfusion. Additionally, oleuropein has been found to decrease COX-2 expression, suppress IL-17 in mucosa and supernatant, and attenuate inflammatory damage in colonic biopsy cultures or samples of ulcerative colitis. Furthermore, oleuropein was found to significantly increase radiosensitivity of nasopharyngeal carcinoma cells by reducing expression of HIF1alpha, in addition to altering expressions of miRNAs and genes.

Product Info

Cas No.

32619-42-4
Purity

≥98%
Formula

C25H32O13
Formula Wt.

540.52
Chemical Name

(2S,3E,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetic acid, 2-(3,4-dihydroxyphenyl)ethyl ester
IUPAC Name

methyl (4S,5E,6S)-4-[2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl]-5-ethylidene-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylate
Synonym

Oleoeuropein
Solubility

DMSO:100 mg/mL (185.01 mM) Water:100 mg/mL warmed (185.01 mM) Ethanol:100 mg/mL warmed (185.01 mM)
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

O446185 MSDS PDF
Info Sheet

O446185 Info Sheet PDF

References

Garcia-Molina G, Peters E, Palmeri R, et al. Enzymatic synthesis of hydroxytyrosol from oleuropein for valorization of an agricultural waste. Bioengineered. 2024 Dec;15(1):2396647. PMID: 39235136.

Zhao Q, Bai Y, Li C, et al. Oleuropein protects cardiomyocyte against apoptosis via activating the reperfusion injury salvage kinase pathway in vitro. Evid Based Complement Alternat Med. 2017. 2017:2109018. PMID: 28491103.

Larussa T, Oliverio M, Suraci E, et al. Oleuropein decreases cyclooxygenase-2 and interleukin-17 expression and attenuates inflammatory damage in colonic samples from ulcerative colitis patients. Nutrients. 2017 Apr 15;9(4).pii:E391. PMID: 28420140.

Xu T, Xiao D. Oleuropein enhances radiation sensitivity of nasopharyngeal carcinoma by downregulating PDRG1 through HIF1alpha-repressed microRNA-519d. J Exp Clin cancer Res. 2017 Jan 5;36(1):3. PMID: 28057028.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V3444

    Vilazodone

    5-HT1A partial agonist, SERT inhibitor.

    ≥98%
  • R3221

    3-Formylrifamycin

    Rifamycin derivative, induces pore formation in...

    ≥98%
  • R520002

    RN-1747

    TRPV4 agonist

    ≥98%
  • C9614

    Cyclosporin H

    Cyclosporin metabolite; formyl peptide inhibito...

    ≥96%
  • V3277

    Vitamin E

    Synthetic vitamin E, antioxidant.

    ≥98%
  • G7443

    GSK-429286A

    ROCK1/2 inhibitor, potential RSK and p70S6K inh...

    ≥98%
  • R5774

    Roscovitine

    CDK inhibitor, L-type Ca2+ channel blocker.

    ≥98%
  • L1982

    Leupeptin Hemisulfate

    Protease inhibitor.

    ≥95%
  • P0245

    Palmatine Chloride Hydrate

    Isoquinoline alkaloid found in Corydalis, Phell...

    ≥96%
  • P6957

    Protopanaxadiol

    Triterpene sapogenin found in species of Panax;...

    ≥98%
  • V0269

    Vardenafil Dihydrochloride

    PDE5 inhibitor.

    ≥99%
  • O0977

    Octopamine Hydrochloride

    Endogenous biogenic amine, norepinephrine-like ...

    ≥98%
  • B564086

    Boceprevir

    Inhibits HCV replication

    ≥98%
  • T1854

    Tenofovir Monohydrate

    Nucleotide analog; RT inhibitor.

    ≥98%
  • L0362

    Lapatinib free base

    Inhibitor of EGFR/HER2 (ErbB2).

    ≥99%
  • A5037

    Amiodarone Hydrochloride

    Voltage-gated Na+, Ca2+, K+ channel blocker, α...

    ≥98%
  • D0253

    Danazol

    Ethisterone derivative, synthetic steroid, used...

    ≥99%
  • L9704

    LY-2603618

    Chk1 inhibitor.

    ≥98%
  • L960002

    LY-294002 Hydrochloride

    Inhibitor of PI3K.

    ≥98%
  • R1627

    Regorafenib Anhydrous

    Multikinase inhibitor.

    ≥99%