LKT Labs

Biochemicals for Life Science Research

Oleuropein

Product ID O446185
Cas No. 32619-42-4
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $38.60 In stock
25 mg $71.70 In stock
100 mg $204.00 In stock
250 mg $385.90 In stock
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Description

Oleuropein is a bioactive compound found in all parts of the olive tree. Oleuropein has been shown to reduce intracellular ROS generation, inhibit apoptosis, stabilize mitochondrial membrane potential, modulate apoptotic proteins, and increase phosphorylation of Akt and ERK1/2 in neonatal rat cardiomyocytes subjected to simulation of ischemia/reperfusion. Additionally, oleuropein has been found to decrease COX-2 expression, suppress IL-17 in mucosa and supernatant, and attenuate inflammatory damage in colonic biopsy cultures or samples of ulcerative colitis. Furthermore, oleuropein was found to significantly increase radiosensitivity of nasopharyngeal carcinoma cells by reducing expression of HIF1alpha, in addition to altering expressions of miRNAs and genes.

Product Info

Cas No.

32619-42-4
Purity

≥98%
Formula

C25H32O13
Formula Wt.

540.52
Chemical Name

(2S,3E,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetic acid, 2-(3,4-dihydroxyphenyl)ethyl ester
Solubility

DMSO:100 mg/mL (185.01 mM) Water:100 mg/mL warmed (185.01 mM) Ethanol:100 mg/mL warmed (185.01 mM)
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

O446185 MSDS PDF
Info Sheet

O446185 Info Sheet PDF

References

Zhao Q, Bai Y, Li C, et al. Oleuropein protects cardiomyocyte against apoptosis via activating the reperfusion injury salvage kinase pathway in vitro. Evid Based Complement Alternat Med. 2017. 2017:2109018. PMID: 28491103.

Larussa T, Oliverio M, Suraci E, et al. Oleuropein decreases cyclooxygenase-2 and interleukin-17 expression and attenuates inflammatory damage in colonic samples from ulcerative colitis patients. Nutrients. 2017 Apr 15;9(4).pii:E391. PMID: 28420140.

Xu T, Xiao D. Oleuropein enhances radiation sensitivity of nasopharyngeal carcinoma by downregulating PDRG1 through HIF1alpha-repressed microRNA-519d. J Exp Clin cancer Res. 2017 Jan 5;36(1):3. PMID: 28057028.

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