• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Olopatadine Hydrochloride

Olopatadine Hydrochloride

Product ID O4658
Cas No. 140462-76-6
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $58.20 In stock
25 mg $116.80 In stock
100 mg $321.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Olopatadine hydrochloride is an antihistamine clinically used to treat allergic rhinitis and allergic conjunctivitis. This compound acts as a mast cell stabilizer, preventing histamine and TNF-α release from mast cells. Olopatadine is also an antagonist at histamine H1/2/3 receptors, although it is selective primarily for H1 receptors over other subtypes. Additionally, olopatadine suppresses allergy-related increases in substance P, NGF, and VEGF.

Product Info

Cas No.

140462-76-6

Purity

≥99%

Formula

C21H23NO3 • HCl

Formula Wt.

373.87

IUPAC Name

2-[(11Z)-11-[3-(dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid;hydrochloride InChI: InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;

Melting Point

245-248°C

Solubility

H2O: ≥20 mg/mL DMSO: 37mg/ml

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

O4658 MSDS PDF

Info Sheet

O4658 Info Sheet PDF

References

Tamura T. Olopatadine ophthalmic solution suppresses substance P release in the conjunctivitis models. Asia Pac Allergy. 2012 Apr;2(2):115-21. PMID: 22701861.

Tamura T. Investigation of the antiallergic activity of olopatadine on rhinitis induced by intranasal instillation of antigen in sensitized rats using thermography. Asia Pac Allergy. 2011 Oct;1(3):138-44. PMID: 22053310.

Roland PS, Ryan MW, Wall GM. Olopatadine nasal spray for the treatment of seasonal allergic rhinitis in patients aged 6 years and older. Expert Opin Pharmacother. 2010 Jun;11(9):1559-67. PMID: 20482305.

Leonardi A, Quintieri L. Olopatadine: a drug for allergic conjunctivitis targeting the mast cell. Expert Opin Pharmacother. 2010 Apr;11(6):969-81. PMID: 20307221.

Sharif NA, Xu SX, Yanni JM. Olopatadine (AL-4943A): ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitis. J Ocul Pharmacol Ther. 1996 Winter;12(4):401-7. PMID: 8951676.

Yanni JM, Stephens DJ, Miller ST, et al. The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. J Ocul Pharmacol Ther. 1996 Winter;12(4):389-400. PMID: 8951675.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D1627

    Dehydrocostus Lactone

    Sesquiterpene lactone found in Saussurea.

    ≥98%
  • B5072

    BMS-754807

    InsR and IGF-1R inhibitor.

    ≥99%
  • D0032

    Daidzein

    Phytoestrogen, isoflavone found in various plan...

    ≥97%
  • T1778

    2,3,5,6-Tetramethylpyrazine

    Dihydropyrazine found in Ligusticum walliichi. ...

    ≥98%
  • T0114

    Taxinin M

    Taxane found in Taxus; DNA polymerase inhibitor...

    ≥98%
  • V0146

    Valsartan

    AT1 inhibitor.

    ≥98%
  • P3561

    Piperlongumine

    Found in Piper longum; TxA2 antagonist, ubiquit...

    ≥98%
  • G0152

    Ganciclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • N344784

    N-Nitroso Valsartan

    Valsartan impurity

    ≥98%
  • P2012

    PF-04217903

    Triazolopyrazine; c-MET inhibitor.

    ≥98%
  • C2961

    Chondroitin Sulfate, chicken

    Polyanionic sulfated glycosaminoglycan, endogen...

    ≥90%
  • M1646

    Melanin Concentrating Hormone, human/mouse/rat

    Endogenous peptide hormon involved in energy ho...

    ≥98%
  • B7973

    Busulfan

    Alkyl sulfonate; DNA alkylator.

    ≥98%
  • F1853

    Fenofibrate

    Fibrate; PPARα agonist.

    ≥98%
  • S8098

    SU-1498

    Tyrphostin; VEGFR inhibitor.

    ≥99%
  • C4759

    Clozapine N-oxide

    Inert clozapine analog, activates specialized G...

    ≥98%
  • C1627

    Cefaclor Monohydrate

    β-lactam cephalosporin; penicillin binding pro...

    ≥97%
  • A7577

    Astilbin

    Flavonoid found in various plant sources.

    ≥99%
  • L3453

    Linezolid

    Oxazolidinone; protein synthesis inhibitor.

    ≥99%
  • D023721

    Dasatinib

    Multikinase inhibitor.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only