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Olopatadine Hydrochloride

Olopatadine Hydrochloride

Product ID O4658
Cas No. 140462-76-6
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $58.20 In stock
25 mg $116.80 In stock
100 mg $321.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Olopatadine hydrochloride is an antihistamine clinically used to treat allergic rhinitis and allergic conjunctivitis. This compound acts as a mast cell stabilizer, preventing histamine and TNF-α release from mast cells. Olopatadine is also an antagonist at histamine H1/2/3 receptors, although it is selective primarily for H1 receptors over other subtypes. Additionally, olopatadine suppresses allergy-related increases in substance P, NGF, and VEGF.

Product Info

Cas No.

140462-76-6

Purity

≥99%

Formula

C21H23NO3 • HCl

Formula Wt.

373.87

IUPAC Name

2-[(11Z)-11-[3-(dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid;hydrochloride InChI: InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;

Melting Point

245-248°C

Solubility

H2O: ≥20 mg/mL DMSO: 37mg/ml

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

O4658 MSDS PDF

Info Sheet

O4658 Info Sheet PDF

References

Tamura T. Olopatadine ophthalmic solution suppresses substance P release in the conjunctivitis models. Asia Pac Allergy. 2012 Apr;2(2):115-21. PMID: 22701861.

Tamura T. Investigation of the antiallergic activity of olopatadine on rhinitis induced by intranasal instillation of antigen in sensitized rats using thermography. Asia Pac Allergy. 2011 Oct;1(3):138-44. PMID: 22053310.

Roland PS, Ryan MW, Wall GM. Olopatadine nasal spray for the treatment of seasonal allergic rhinitis in patients aged 6 years and older. Expert Opin Pharmacother. 2010 Jun;11(9):1559-67. PMID: 20482305.

Leonardi A, Quintieri L. Olopatadine: a drug for allergic conjunctivitis targeting the mast cell. Expert Opin Pharmacother. 2010 Apr;11(6):969-81. PMID: 20307221.

Sharif NA, Xu SX, Yanni JM. Olopatadine (AL-4943A): ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitis. J Ocul Pharmacol Ther. 1996 Winter;12(4):401-7. PMID: 8951676.

Yanni JM, Stephens DJ, Miller ST, et al. The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. J Ocul Pharmacol Ther. 1996 Winter;12(4):389-400. PMID: 8951675.

Custom Order

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