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Oltipraz

Oltipraz

Product ID O4578
Cas No. 64224-21-1
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $111.70 In stock
250 mg $207.50 In stock
500 mg $321.90 In stock
1 g $543.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Oltipraz is an activator of Nrf2 that exhibits anti-fibrotic, anti-diabetic, anti-parasitic, anti-angiogenic, and anticancer chemotherapeutic activities. Oltipraz induces phase II enzymes such as NADPH:quinone reductase. Oltipraz also displays efficacy in the treatment of Schistosoma infections. In vivo, oltipraz inhibits diet-induced development of hepatic fibrosis. In high-fat diet-fed animal models, oltipraz prevents decreases in expression of GLUT4, Nrf2, superoxide dismutase, and heme oxygenase 1 and suppresses increases in protein oxidation and iNOS production, improving glucose disposal and overall body weight. In animal models of cancer, this compound decreases vessel density, expression of VEGF, and tumor growth; additionally, oltipraz increases ubiquitination and suppresses expression of HIF-1α.

Product Info

Cas No.

64224-21-1

Purity

≥98%

Formula

C8H6N2S3

Formula Wt.

226.34

Chemical Name

4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione

IUPAC Name

4-methyl-5-pyrazin-2-yldithiole-3-thione

Synonym

BRN 0978110

Melting Point

165-166°C

Solubility

Soluble in methanol.

Appearance

Bright red crystal powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

O4578 MSDS PDF

Info Sheet

O4578 Info Sheet PDF

References

Shimozono R, Asaoka Y, Yoshizawa Y, et al. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol Pharmacol. 2013 Jul;84(1):62-70. PMID: 23592516.

Yu Z, Shao W, Chiang Y, et al. Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice. Diabetologia. 2011 Apr;54(4):922-34. Erratum in: Diabetologia. 2011 Apr;54(4):989. PMID: 21161163.

Lee WH, Kim YW, Choi JH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8(10):2791-802. PMID: 19789218.

Morsy GH. Parasitological and histo-pathological studies on schistosomiasis mansoni infected mice and treated with praziquatel and/or oltipraz. J Egypt Soc Parasitol. 2009 Aug;39(2):687-701. PMID: 19795775.

Merrell MD, Jackson JP, Augustine LM, et al. The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metab Dispos. 2008 Aug;36(8):1716-21. PMID: 18474683.

Custom Order

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