• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Oltipraz

Oltipraz

Product ID O4578
Cas No. 64224-21-1
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $111.70 In stock
250 mg $207.50 In stock
500 mg $321.90 In stock
1 g $543.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Oltipraz is an activator of Nrf2 that exhibits anti-fibrotic, anti-diabetic, anti-parasitic, anti-angiogenic, and anticancer chemotherapeutic activities. Oltipraz induces phase II enzymes such as NADPH:quinone reductase. Oltipraz also displays efficacy in the treatment of Schistosoma infections. In vivo, oltipraz inhibits diet-induced development of hepatic fibrosis. In high-fat diet-fed animal models, oltipraz prevents decreases in expression of GLUT4, Nrf2, superoxide dismutase, and heme oxygenase 1 and suppresses increases in protein oxidation and iNOS production, improving glucose disposal and overall body weight. In animal models of cancer, this compound decreases vessel density, expression of VEGF, and tumor growth; additionally, oltipraz increases ubiquitination and suppresses expression of HIF-1α.

Product Info

Cas No.

64224-21-1

Purity

≥98%

Formula

C8H6N2S3

Formula Wt.

226.34

Chemical Name

4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione

IUPAC Name

4-methyl-5-pyrazin-2-yldithiole-3-thione

Synonym

BRN 0978110

Melting Point

165-166°C

Solubility

Soluble in methanol.

Appearance

Bright red crystal powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

O4578 MSDS PDF

Info Sheet

O4578 Info Sheet PDF

References

Shimozono R, Asaoka Y, Yoshizawa Y, et al. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol Pharmacol. 2013 Jul;84(1):62-70. PMID: 23592516.

Yu Z, Shao W, Chiang Y, et al. Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice. Diabetologia. 2011 Apr;54(4):922-34. Erratum in: Diabetologia. 2011 Apr;54(4):989. PMID: 21161163.

Lee WH, Kim YW, Choi JH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8(10):2791-802. PMID: 19789218.

Morsy GH. Parasitological and histo-pathological studies on schistosomiasis mansoni infected mice and treated with praziquatel and/or oltipraz. J Egypt Soc Parasitol. 2009 Aug;39(2):687-701. PMID: 19795775.

Merrell MD, Jackson JP, Augustine LM, et al. The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metab Dispos. 2008 Aug;36(8):1716-21. PMID: 18474683.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G3453

    20(S)-Ginsenoside Rh2

    Triterpene saponin found in Panax.

    ≥98%
  • C2961

    Chondroitin Sulfate, chicken

    Polyanionic sulfated glycosaminoglycan, endogen...

    ≥90%
  • A1330

    Adipokinetic Hormone

    Neuropeptide hormone found in insects, involved...

    ≥95%
  • C0377

    Catharanthine Sulfate

    Alkaloid found in Catharanthus, precursor in sy...

    ≥98%
  • P1754

    Penciclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • D1773

    Deshydroxy LY-411575

    γ-Secretase inhibitor.

    ≥98%
  • D0032

    Daidzein

    Phytoestrogen, isoflavone found in various plan...

    ≥97%
  • A0964

    Adrenocorticotropic Hormone (1-13), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • T1004

    Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity

    Synthesis impurity

    ≥92%
  • P3348

    Pimecrolimus

    Calcineurin inhibitor, potential TRPV1 agonist....

    ≥99%
  • T3033

    Thienyldodecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • P3461

    Pipemidic Acid

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • R0109

    Racecadotril

    Enkephalinase inhibitor.

    ≥98%
  • G346851

    Givinostat Hydrochloride

    Non-selective HDAC inhibitor.

    ≥98%
  • B1769

    Bergenin

    Trihydroxybenzoic acid glycoside found in Berge...

    ≥98%
  • B7118

    Brevetoxin 3 42-carboxylic Acid

    Polyether neurotoxin found in Karenia brevis; N...

    ≥95%
  • C5662

    Copper Bis-3,5-diisopropylsalicylate

    Antioxidant.

    ≥97%
  • D0262

    Dapiprazole Hydrochloride

    α1-Adrenergic antagonist.

    ≥98%
  • A0962

    Adrenocorticotropic Hormone (1-4)

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • D0005

    Dabrafenib Mesylate

    B-Raf and c-Raf inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only