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Omeprazole related compound A (omeprazole sulfone) is a metabolite of omeprazole found in individuals who are taking the drug. The isozyme, CYP3A4, of the P450 drug metabolizing enzyme appears to be responsible for the oxidation of the sulfoxide of omeprazole in a stereoselective manner to its sulfone .
| Cas No. | 88546-55-8 |
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| Purity | ≥99% |
| Formula | C17H19N3O4S |
| Formula Wt. | 361.42 |
| Chemical Name | 5-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfonyl)-1H-benzo[d]imidazole |
| IUPAC Name | 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfonyl]-1H-benzimidazole |
| Synonym | Omeprazole sulfone; Omeprazole sulphone; omeprazole impurity D; Omeprazole metabolite Omeprazole sulfone; UNII-76X040Z74OÂ Â Â |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Mihaly GW, Prichard PJ, Smallwood RA, et al. Simultaneous high-performance liquid chromatographic analysis of omeprazole and its sulphone and sulphide metabolites in human plasma and urine. J Chromatogr. 1983;278(2):311-9. PMID: 6668312.
Abelö A1, Andersson TB, Antonsson M, et al. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab Dispos. 2000;28(8):966-72. PMID: 10901708