• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Palbociclib Isethionate

Palbociclib Isethionate

Product ID P0344
Cas No. 827022-33-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $73.50 In stock
10 mg $94.50 In stock
25 mg $183.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Palbociclib is an inhibitor of CDK4 and CDK6 that displays anticancer chemotherapeutic and nephroprotective activities; it is currently in clinical trials as a potential treatment for breast cancer. Palbociclib induces G0/G1 phase cell cycle arrest in renal proximal tubule cells, protecting animals against nephrotoxicity and inflammation induced by other chemotherapeutics. Palbociclib also induces cell cycle arrest in cellular and animal models of glioma, increasing overall survival times. In animal models of retinoblastoma, this compound inhibits cell proliferation, and induces G1 phase cell cycle arrest and tumor regression.

Product Info

Cas No.

827022-33-3

Purity

≥98%

Formula

C24H29N7O2 • C2H6O4S

Formula Wt.

573.66

IUPAC Name

2-Hydroxyethanesulfonic acid - 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(1-piperazinyl)-2-pyridinyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one (1:1)

Synonym

PD0332991-0054, PF00080665-73

Solubility

Water 10 mg/mL warmed (17.43 mM) DMSO Insoluble Ethanol Insoluble

Appearance

Yellow to pale yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P0344 MSDS PDF

Info Sheet

P0344 Info Sheet PDF

References

Vaughn DJ, Hwang W, Lal P, et al. Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors. Cancer. 2014 Dec 18. [Epub ahead of print]. PMID: 25522918.

DiRocco DP, Bisi J, Roberts P, et al. CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury. Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F379-88. PMID: 24338822.

Barton KL, Misuraca K, Cordero F, et al. PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. PLoS One. 2013 Oct 2;8(10):e77639. PMID: 24098593.

Fry DW, Harvey PJ, Keller PR, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38. PMID: 15542782.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T6930

    Triclosan Methyl Ether

    Diarylether; bacterial ENR binder, fatty acid s...

    ≥99%
  • L0107

    Lactacystin

    Found in Streptomyces; proteasome inhibitor.

    ≥98%
  • V1871

    Veratridine

    Binds to neurotoxin receptor site 2 on voltage-gat...
    ≥98%
  • E537331

    Enniatin Complex

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • D3330

    Dihydrotanshinone

    Found in Salvia; fatty acid synthase and AChE i...

    ≥90%
  • B8274

    Buspirone Hydrochloride

    Azapirone; α1-adrenergic and 5-HT1A partial ag...

    ≥98%
  • V3378

    Vitamin B12

    Coenzyme, vitamin found in dairy, meat, eggs, f...

    ≥97%
  • M3584

    Mivacurium

    Non-depolarizing NMJ blocker; nAChR antagonist....

    ≥98%
  • O7332

    OSI-027

    mTOR inhibitor.

    ≥99%
  • T1298

    TDZD-8

    GSK-3β inhibitor.

    ≥98%
  • P0146

    Palmitoyl-L-carnitine

    Long chain acylcarnitine involved in fatty acid...

    ≥98%
  • A2500

    AG-1478

    EGFR inhibitor.

    ≥98%
  • S5868

    Sorafenib

    c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5...

    ≥98%
  • C1635

    Ceftazidime Hydrate

    β-lactam cephalosporin; penicillin binding pro...

    ≥97%
  • E5241

    Met-Enkephalin

    Endogenous opioid peptide; δOR and μOR agonis...

    ≥95%
  • E7310

    Esculin

    Coumarin glucoside found in Aesculus, Daphne, a...

    ≥98%
  • L3374

    Lisinopril Dihydrate

    Enalapril analog; ACE inhibitor.

    ≥98%
  • S6235

    Spironolactone

    Mineralocorticoid, aldosterone, AR antagonist, ...

    ≥97%
  • C9200

    CX-6258

    Pim kinase inhibitor.

    ≥98%
  • P3563

    Piperlonguminine

    Found in Piper longum.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only