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Panaxadiol

Panaxadiol

Product ID P0253
Cas No. 19666-76-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $108.20 In stock
5 mg $275.10 In stock
10 mg $477.60 In stock
25 mg $954.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. Panaxadiol inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential. This compound also increases superoxide dismutase activity and decreases malondialdehyde levels, improving cardiac function in animal models of burn injury. Additionally, panaxadiol improves efficacy of co-administered chemotherapeutics such as cyclophosphamide in animal models of melanoma and lung carcinoma.

Product Info

Cas No.

19666-76-3

Purity

≥98%

Formula

C30H52O3

Formula Wt.

460.74

IUPAC Name

4,4,8,10,14-pentamethyl-17-(2,6,6-trimethyloxan-2-yl)-2,3,5,6,7,9,11,12, 13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol

Solubility

Soluble in DMSO.

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P0253 MSDS PDF

Info Sheet

P0253 Info Sheet PDF

References

Wang Z, Zheng Q, Liu K, et al. Ginsenoside Rh(2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide. Basic Clin Pharmacol Toxicol. 2006 Apr;98(4):411-5. PMID: 16623867.

Wang ZF, Xiao JS, Yan SZ, et al. Protective effects of panaxadiol saponins on cardiac functions in burned rats. Zhongguo Yao Li Xue Bao. 1995 Jul;16(4):345-8. PMID: 7668107.

Zhang WJ, Zhong GG, Jiang Y, et al. Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):173-6. PMID: 7516611.

Custom Order

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