Pancreastatin, porcine

Name: Pancreastatin, porcine
SKU: P0352
Availability: BackOrder

Product ID P0352

Cas No.

Purity ≥98%

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Description

Pancreastatin is an endogenous peptide derived from chromogranin-A that regulates insulin action, inhibiting insulin secretion and increasing glucagon secretion. Pancreastatin binds and inhibits GRP78, decreasing insulin-stimulated glucose uptake and expression of G6Pase. This peptide displays pro-diabetic activity and induces glycogenolysis and lipolysis. Pancreastatin is also used as a biomarker to detect neuroendocrine tumors and shows some correlation with diabetes and hypertension.

Product Info

Purity	≥98%
Formula	C₂₁₄H₃₃₀N₆₈O₇₆S
Formula Wt.	5103.45
Synonym	PST
Solubility	Soluble in water.

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

Info Sheet	P0352 Info Sheet PDF

References

Biswas N, Friese RS, Gayen JR, et al. Discovery of a novel target for the dysglycemic chromogranin A fragment pancreastatin: interaction with the chaperone GRP78 to influence metabolism. PLoS One. 2014 Jan 20;9(1):e84132. PMID: 24465394.

Rustagi S, Warner RR, Divino CM. Serum pancreastatin: the next predictive neuroendocrine tumor marker. J Surg Oncol. 2013 Aug;108(2):126-8. PMID: 23775817.

Sánchez-Margalet V, González-Yanes C, Najib S, et al. Metabolic effects and mechanism of action of the chromogranin A-derived peptide pancreastatin. Regul Pept. 2010 Apr 9;161(1-3):8-14. PMID: 20184923.

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Pancreastatin, porcine

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

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