LKT Labs

Biochemicals for Life Science Research

Pancreastatin, porcine

Product ID P0352
Cas No.
Purity ≥98%
Product Unit SizeCostQuantityStock
0.5 mg $725.00 Please Inquire
1 mg $1,200.00 Please Inquire
2.5 mg $2,000.00 Please Inquire
Bulk Quote

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Description

Pancreastatin is an endogenous peptide derived from chromogranin-A that regulates insulin action, inhibiting insulin secretion and increasing glucagon secretion. Pancreastatin binds and inhibits GRP78, decreasing insulin-stimulated glucose uptake and expression of G6Pase. This peptide displays pro-diabetic activity and induces glycogenolysis and lipolysis. Pancreastatin is also used as a biomarker to detect neuroendocrine tumors and shows some correlation with diabetes and hypertension.

Product Info

Purity

≥98%
Formula

C214H330N68O76S
Formula Wt.

5103.45
Synonym

PST
Solubility

Soluble in water.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

Info Sheet

P0352 Info Sheet PDF

References

Biswas N, Friese RS, Gayen JR, et al. Discovery of a novel target for the dysglycemic chromogranin A fragment pancreastatin: interaction with the chaperone GRP78 to influence metabolism. PLoS One. 2014 Jan 20;9(1):e84132. PMID: 24465394.

Rustagi S, Warner RR, Divino CM. Serum pancreastatin: the next predictive neuroendocrine tumor marker. J Surg Oncol. 2013 Aug;108(2):126-8. PMID: 23775817.

Sánchez-Margalet V, González-Yanes C, Najib S, et al. Metabolic effects and mechanism of action of the chromogranin A-derived peptide pancreastatin. Regul Pept. 2010 Apr 9;161(1-3):8-14. PMID: 20184923.

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