• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Parthenolide

Parthenolide

Product ID P0270
Cas No. 20554-84-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $78.80 Please Inquire
100 mg $157.50 Please Inquire
250 mg $315.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Parthenolide is a sesquiterpene lactone found in Tanacetum that exhibits anticancer chemotherapeutic, anti-metastatic, anti-angiogenic, anti-inflammatory, and antinociceptive activities. Parthenolide acts as a partial agonist at transient receptor potential ankyrin 1 (TRPA1) channels and desensitizes them, preventing release of calcitonin gene-related peptide (CGRP). Additionally, parthenolide inhibits ATPase activity of NLRP3 and protease activity of caspase 1. In multiple myeloma cells, parthenolide decreases expression of NF-κB, VEGF, and IL-6 and increases expression of IκB kinase, inhibiting cell migration and tubule formation. In non-small cell lung cancer (NSCLC) cells, parthenolide decreases levels of MCL-1 and increases levels of MAIP-1, triggering ER stress and inducing cell cycle arrest and apoptosis. In breast cancer cells, this compound activates NADPH oxidase and increases ROS generation, increasing levels of p-JNK and downregulating NF-κB, VEGF, and matrix metalloproteinases 2 and 9 (MMP2/9); in vivo, parthenolide inhibits tumor growth and metastasis.

Product Info

Cas No.

20554-84-1

Purity

≥98%

Formula

C15H20O3

Formula Wt.

248.32

IUPAC Name

(1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one

Melting Point

112-115°C

Solubility

DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane.

Appearance

White Crystals

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P0270 MSDS PDF

Info Sheet

P0270 Info Sheet PDF

Brochures

TRP Channel Modulator Flyer

References

Zhao X, Liu X, Su L. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014 Jan 6;33(1):3. PMID: 24387758.

Materazzi S, Benemei S, Fusi C, et al. Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain. 2013 Dec;154(12):2750-8. PMID: 23933184.

D'Anneo A, Carlisi D, Lauricella M, et al. Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer. Cell Death Dis. 2013 Oct 31;4:e891. PMID: 24176849.

Juliana C, Fernandes-Alnemri T, Wu J, et al. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J Biol Chem. 2010 Mar 26;285(13):9792-802. PMID: 20093358.

https://en.wikipedia.org/wiki/Parthenolide

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C9809

    Cyclopiazonic Acid

    SERCA inhibitor.

    ≥98%, TLC
  • Y0052

    Yangonin

    Dienolide kavalactone originally found in Piper...

    ≥98%
  • P2922

    Phenylhexyl Isothiocyanate

    ITC found in cruciferous vegetables; HDAC inhib...

    ≥98%
  • R2810

    Recombinant Multi-epitope Chimeric HIV Antigen 1

    Recombinant HIV-1 multi-epitope chimeric antige...

    ≥95%
  • G4484

    Glucagon-like Peptide II, rat

    Endogenous peptide hormone, involved in intesti...

    ≥95%
  • A0920

    N-Acetyl-S-(N′-phenethylthiocarbamoyl)-L-cysteine

    N-acetyl cysteine conjugate of phenethylisothio...

    ≥95%
  • C9876

    CYT-387

    JAK2 inhibitor.

    ≥98%
  • I5315

    Indomethacin

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • D0025

    DAMGO

    Synthetic peptice; μOR agonist.

    ≥95%
  • R5878

    Rotenone

    Micronuclei formation inducer, antimitotic, oxi...

    ≥97%
  • P7608

    PTC124

    Read-through agent and nonsense mutation target...

    ≥98%
  • I5440

    INK128

    mTOR inhibitor.

    ≥99%
  • C9778

    Cytarabine

    Pyrimidine nucleoside (cytidine) analog; DNA ch...

    ≥98%
  • V1872

    Vesicular Stomatitis Virus Peptide

    Peptide fragment of VSV; LDLR agonist.

    ≥95%
  • K740640

    KSQ-4279

    USP1 inhibitor

    ≥98%
  • A2420

    A-769662

    AMPK activator.

    ≥98%
  • T6832

    Triamcinolone Acetonide

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • S0381

    Sauvagine

    CRF-related peptide found in amphibians.

    ≥98%
  • L1785

    Levofloxacin Hemihydrate

    Fluoroquinolone, S-(-) isomer of ofloxacin; top...

    ≥98%
  • B5609

    Boc-GRR-AMC

    Peptide, protease substrate.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only