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Paxilline is a neuroactive mycotoxin initially produced by species of Penicillum and Aspergillus. In vitro and in vivo, paxilline inhibits Ca2+/voltage-sensitive K+ (BK) channels. Paxilline also competitively inhibits sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), preventing Ca2+ release and phosphoenzyme formation.
| Cas No. | 57186-25-1 |
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| Purity | ≥98% |
| Formula | C27H33NO4 |
| Formula Wt. | 435.56 |
| IUPAC Name | (1S,2R,5S,7R,11S,14S)-11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one |
| Melting Point | 252-269°C |
| Solubility | Acetone, Methanol, and DMSO. |
| Appearance | White Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Borchert GH, Hlaváčková M, Kolář F. Pharmacological activation of mitochondrial BK(Ca) channels protects isolated cardiomyocytes against simulated reperfusion-induced injury. Exp Biol Med (Maywood). 2013 Feb;238(2):233-41. PMID: 23576804.
Bilmen JG, Wootton LL, Michelangeli F. The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline. Arch Biochem Biophys. 2002 Oct 1;406(1):55-64. PMID: 12234490.