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Pazopanib

Pazopanib

Product ID P0397
Cas No. 444731-52-6
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $52.50 In stock
25 mg $112.60 In stock
100 mg $277.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pazopanib is an inhibitor of VEGFR, PDGFR, and c-Kit that displays anticancer chemotherapeutic and anti-angiogenic activities. Pazopanib is clinically used to treat metastatic renal cell carcinoma, but shows potential for a wide variety of other cancers, including ovarian cancer and non-small cell lung cancer (NSCLC). In vitro and in vivo, pazopanib inhibits cell proliferation and angiogenesis, preventing tumor growth. This compound also inhibits wild-type B-Raf, preventing activation of p-ERK1/2 and p-MEK1/2, decreasing brain metastasis volume in animal models of breast cancer.

Product Info

Cas No.

444731-52-6

Purity

≥97%

Formula

C21H23N7O2S

Formula Wt.

437.53

Chemical Name

5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide

IUPAC Name

5-[[4-[(2, 3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2- methylbenzenesulfonamide

Synonym

GSK-VEG10003; GW786034B; GW-786034

Melting Point

301-313°C

Appearance

Off-white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P0397 MSDS PDF

Info Sheet

P0397 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Pick AM, Nystrom KK. Pazopanib for the treatment of metastatic renal cell carcinoma. Clin Ther. 2012 Mar;34(3):511-20. PMID: 22341567.

Gril B, Palmieri D, Qian Y, et al. Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis. Clin Cancer Res. 2011 Jan 1;17(1):142-53. PMID: 21081656.

Hamberg P, Verweij J, Sleijfer S. (Pre-)clinical pharmacology and activity of pazopanib, a novel multikinase angiogenesis inhibitor. Oncologist. 2010;15(6):539-47. PMID: 20511320.

Custom Order

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