• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Pazopanib

Pazopanib

Product ID P0397
Cas No. 444731-52-6
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $52.50 In stock
25 mg $112.60 In stock
100 mg $277.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pazopanib is an inhibitor of VEGFR, PDGFR, and c-Kit that displays anticancer chemotherapeutic and anti-angiogenic activities. Pazopanib is clinically used to treat metastatic renal cell carcinoma, but shows potential for a wide variety of other cancers, including ovarian cancer and non-small cell lung cancer (NSCLC). In vitro and in vivo, pazopanib inhibits cell proliferation and angiogenesis, preventing tumor growth. This compound also inhibits wild-type B-Raf, preventing activation of p-ERK1/2 and p-MEK1/2, decreasing brain metastasis volume in animal models of breast cancer.

Product Info

Cas No.

444731-52-6

Purity

≥97%

Formula

C21H23N7O2S

Formula Wt.

437.53

Chemical Name

5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide

IUPAC Name

5-[[4-[(2, 3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2- methylbenzenesulfonamide

Synonym

GSK-VEG10003; GW786034B; GW-786034

Melting Point

301-313°C

Appearance

Off-white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P0397 MSDS PDF

Info Sheet

P0397 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Pick AM, Nystrom KK. Pazopanib for the treatment of metastatic renal cell carcinoma. Clin Ther. 2012 Mar;34(3):511-20. PMID: 22341567.

Gril B, Palmieri D, Qian Y, et al. Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis. Clin Cancer Res. 2011 Jan 1;17(1):142-53. PMID: 21081656.

Hamberg P, Verweij J, Sleijfer S. (Pre-)clinical pharmacology and activity of pazopanib, a novel multikinase angiogenesis inhibitor. Oncologist. 2010;15(6):539-47. PMID: 20511320.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D0169

    Darifenacin Hydrobromide

    M3 mAChR antagonist.

    ≥98%
  • O6953

    Ornidazole

    5-Nitroimidazole derivative; genotoxic.

    ≥98%
  • I0902

    Icaritin

    Flavonoid found in Epimedium.

    ≥98%
  • L0248

    Laminin Peptide YIGSR

    Laminin-derived peptapeptide.

    ≥98%
  • O9396

    Oxytetracycline

    Tetracycline; protein translation inhibitor.

    ≥96%
  • E5575

    Entacapone

    COMT inhibitor.

    ≥98%
  • D3320

    Difenoconazole

    Triazole; 14-α demethylase inhibitor, potentia...

    ≥98%
  • M7530

    [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone

    Semi-synthetic peptide, melanocortin analog; MC...

    ≥98%
  • G5875

    Gossypol Acetic Acid

    Bcl-2, Bcl-xl, sialyl transferase inhibitor.

    ≥98%
  • B3577

    Bitertanol

    Pesticide; demethylation inhibitor.

    ≥98%
  • R2710

    Recombinant Multi-epitope Chimeric HCV Antigen

    Recombinant Multi-epitope Chimeric HCV antigen....

    ≥95%
  • E9317

    Exemestane

    Aromatase inhibitor.

    ≥97%
  • T0152

    Tandutinib

    FLT3, PDGFR, c-Kit inhibitor.

    ≥98%
  • B1955

    Benztropine Mesylate

    DAT inhibitor.

    ≥99%
  • S9775

    Systemin

    Peptide hormone found in Solanaceae family plan...

    ≥95%
  • C0156

    9-Nitro-20S-camptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%
  • D3203

    Diallyl Tetrasulfide

    Organosulfur found in garlic; Microtubule polym...

    ≥90%
  • P1635

    Peiminine

    Steroidal alkaloid found in Fritillaria; M2 mAC...

    ≥98%
  • I5752

    Ionomycin, Free Acid

    Polyether Ca2+ ionophore.

    ≥98%, TLC, HPLC
  • E7377

    Estriol

    Endogenous steroid hormone, estradiol metabolit...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only