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Pep-1 is a cell-penetrating peptide used to carry large conjugated structures across cell membranes. Pep-1 inhibits low molecular weight hyaluronan binding to toll-like receptor 4 (TLR4) and other receptors. Pep-1 also decreases intestinal and colonic length, decreases expression of IGF-1 and epiregulin, and decreases intestinal epithelial cell proliferation in vivo.
| Purity | ≥95% |
|---|---|
| Formula | C136H195N35O33 |
| Formula Wt. | 2848.23 |
| Solubility | Water (1 mg/mL) |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Meloni BP, Craig AJ, Milech N, et al. The Neuroprotective Efficacy of Cell-Penetrating Peptides TAT, Penetratin, Arg-9, and Pep-1 in Glutamic Acid, Kainic Acid, and In Vitro Ischemia Injury Models Using Primary Cortical Neuronal Cultures. Cell Mol Neurobiol. 2013 Nov 9. [Epub ahead of print]. PMID: 24213248.
Thaete LG, Qu XW, Jilling T, et al. Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice. Reproduction. 2013 Apr 29;145(5):517-26. PMID: 23509372.
Riehl TE, Ee X, Stenson WF. Hyaluronic acid regulates normal intestinal and colonic growth in mice. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G377-88. PMID: 22556141.
Bobone S, Piazzon A, Orioni B, et al. The thin line between cell-penetrating and antimicrobial peptides: the case of Pep-1 and Pep-1-K. J Pept Sci. 2011 May;17(5):335-41. PMID: 21294230.