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Peptide T is an octapeptide fragment of the V2 region of HIV-1 glycoprotein gp120. Peptide T exhibits anti-inflammatory activity, decreasing inflammation and acting as a potential treatment for psoriasis. Peptide T also inhibits HIV entry, blocking binding and infection of HIV strains that require CCR5 for entry. Peptide T also displays some neuroprotective activity, improving cognitive performance in neuroAIDS subjects.
| Cas No. | 106362-32-7 |
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| Purity | ≥98% |
| Formula | C35H55N9O16 |
| Formula Wt. | 857.86 |
| Chemical Name | N-(N-(N2-(N-(N-(N-(N-L-alanyl-L- seryl)-L-thronyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-L-Threonine |
| IUPAC Name | (2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S, 3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxypropanoyl]amino]- 3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl] amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3- hydroxybutanoic acid |
| Solubility | Soluble in water, DMSO. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| Info Sheet |
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Paoletti I, De Gregorio V, Baroni A, et al. Amygdalin analogues inhibit IFN-γ signalling and reduce the inflammatory response in human epidermal keratinocytes. Inflammation. 2013 Dec;36(6):1316-26. PMID: 23933845.
D'ursi A, Caliendo G, Perissutti E, et al. Conformation-activity relationship of peptide T and new pseudocyclic hexapeptide analogs. J Pept Sci. 2007 Jun;13(6):413-21. PMID: 17486694.
Polianova MT, Ruscetti FW, Pert CB, et al. Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 2005 Aug;67(2):83-92. PMID: 16002156.
Ruff MR, Melendez-Guerrero LM, Yang QE, et al. Peptide T inhibits HIV-1 infection mediated by the chemokine receptor-5 (CCR5). Antiviral Res. 2001 Oct;52(1):63-75. PMID: 11530189.
Heseltine PN, Goodkin K, Atkinson JH, et al. Randomized double-blind placebo-controlled trial of peptide T for HIV-associated cognitive impairment. Arch Neurol. 1998 Jan;55(1):41-51. PMID: 9443710.