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PF-06447475

PF-06447475

Product ID P2100
Cas No. 1527473-33-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $110.00 In stock
25 mg $422.00 In stock
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PF-06447475 inhibits leucine-rich repeat kinase 2 (LRRK2), exhibiting neuroprotective activity. In animal models of Parkinson’s disease, this compound suppresses neuroinflammation and neurodegeneration.

Product Info

Cas No.

1527473-33-1

Purity

≥98%

Formula

C17H15N5O

Formula Wt.

305.13

Chemical Name

3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile

IUPAC Name

3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile

Solubility

DMSO 61 mg/mL Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P2100 MSDS PDF

Info Sheet

P2100 Info Sheet PDF

Brochures

LRRK2 Inhibitors

References

Daher JP, Abdelmotilib HA, Hu X, et al. LRRK2 Pharmacological Inhibition Abates α-Synuclein Induced Neurodegeneration. J Biol Chem. 2015 Jun 15. [Epub ahead of print]. PMID: 26078453.

Henderson JL, Kormos BL, Hayward MM, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. PMID: 25353650.

Custom Order

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