LKT Labs

Biochemicals for Life Science Research

Physcion

Physcion

Product ID P2995
Cas No. 521-61-9
Purity ≥96%
Product Unit SizeCostQuantityStock
10 mg $189.20 In stock
25 mg $309.50 In stock
100 mg $946.70 In stock
Bulk Quote

Quicklinks

Description

Physcion is an anthraquinone originally found in several plant sources, including Microsporum, Psorospermum, Rhamnus, and Rheum. Physcion exhibits anticancer, antibiotic, and anti-inflammatory activities. In cervical carcinoma cells, physcion induces apoptosis by downregulating expression of Bcl-2 and upregulating expression of Bax and activation of caspase 3. Physcion also exhibits antibacterial activity against Staphylococcus, Pseudomonas, and Escherichia, as well as antifungal activity against Candida and Aspergillus. In animal models, physcion inhibits iNOS expression and decreases edema volume.

Product Info

Cas No.

521-61-9
Purity

≥96%
Formula

C16H12O5
Formula Wt.

284.26
Chemical Name

1,8-Dihydroxy-3-methoxy-6-methylanthraquinone
IUPAC Name

1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
Synonym

Parietin, Physcione, Rheochrysidin.
Melting Point

203-207C
Solubility

Insoluble in water, slightly soluble in cold alcohol, soluble in boiling alcohol, soluble in benzene, chloroform, ether, acetone, acetic acid, sodium hydroxide and hot sodium carbonate solution, and very slightly soluble in petroleum ether.
Appearance

Yellow powder

Shipping and Storage

Store Temp

4°C
Ship Temp

ambient

Downloads

MSDS

P2995 MSDS PDF
Info Sheet

P2995 Info Sheet PDF

References

Wijesekara I, Zhang C, Van Ta Q, et al. Physcion from marine-derived fungus Microsporum sp. induces apoptosis in human cervical carcinoma HeLa cells. Microbiol Res. 2014 Apr;169(4):255-61. PMID: 24071573.

Locatelli M, Epifano F, Genovese S, et al. Anthraquinone profile, antioxidant and antimicrobial properties of bark extracts of Rhamnus catharticus and R. orbiculatus. Nat Prod Commun. 2011 Sep;6(9):1275-80. PMID: 21941897.

Ghosh S, Das Sarma M, Patra A, et al. Anti-inflammatory and anticancer compounds isolated from Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn. J Pharm Pharmacol. 2010 Sep;62(9):1158-66. PMID: 20796195.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • N1610

    Necrostatin-1

    RIP1 inhibitor.

    ≥99%
  • P1869

    Perindopril Erbumine

    ACE inhibitor.

    ≥95%
  • S6168

    Spirapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • A7203

    AS-703026

    MEK1/2 inhibitor.

    ≥98%
  • O4549

    Olmesartan Medoxomil

    AT1 inhibitor.

    ≥98%
  • O0977

    Octopamine Hydrochloride

    Endogenous biogenic amine, norepinephrine-like ...

    ≥98%
  • G3254

    10-Gingerol

    Phenol found in Zingiber; 5-HT3 antagonist.

    ≥99%
  • W0272

    S-(−)-Warfarin >99%ee

    Coumarin, more potent isomer; VKORC1 inhibitor....

    ≥99%
  • M578522

    Monascin

    Fungal pigment found in red yeast rice

    ≥98%
  • C0247

    Calcineurin Autoinhibitory Peptide

    Peptide; calcineurin inhibitor.

    ≥95%
  • A4445

    Allopurinol

    Purine (hypoxanthine) analog; xanthine oxidase ...

    ≥98%
  • C4535

    Clinafloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • C344761

    Citalopram Chloromethyl Quaternary Ammonium Chloride

    Citalopram analog

    ≥95%
  • S5722

    Sofosbuvir

    Viral RNA polymerase inhibitor.

    ≥98%
  • T3038

    Thienylnonanyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • C2802

    CH5132799

    p110α PI3K inhibitor.

    ≥98%
  • S1853

    Senegenin

    Found in Polygata tennifolia.

    ≥98%
  • L9609

    Lycopene

    Carotene pigment found in red and green fruits ...

    ≥90%
  • S0254

    Sanguinarine Chloride

    Decreases expression of MMPs, PGE2, and COX-2, ...

    ≥98%
  • I4800

    Imatinib free base

    Inhibitor of Abl, c-Kit, and PDGFR.

    ≥99%