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Pitavastatin Calcium

Pitavastatin Calcium

Product ID P3576
Cas No. 147526-32-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $102.00 In stock
25 mg $163.40 In stock
100 mg $428.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pitavastatin is an inhibitor of HMG-CoA reductase that is used to treat atherosclerosis in clinical settings. Pitavastatin exhibits anti-atherosclerotic, anti-inflammatory, immunomodulatory, anti-hyperlipidemic, and antioxidative activities. In vitro and in vivo, pitavastatin increases expression of LEL receptors and liver X receptors (LXRs). Pitavastatin also decreases myocarditis pathology in vivo, through inhibition of STAT3/4, decreases in production of IFN-γ and IL-17, and prevention of Th1 and Th17 cell differentiation. Additionally, pitavastatin downregulates expression of IL-6 and inhibits proliferation of lymphocytes, decreasing graft arterial disease and improving cardiac allograft rejection in animal models. In other animal models, this compound increases levels of HDL, glutathione, glutathione peroxidase, glutathione-S-transferase, superoxide dismutase, and catalase; it also decreases serum triglycerides, lipid peroxides, apolipoprotein B (apoB), and total cholesterol.

Product Info

Cas No.

147526-32-7

Purity

≥98%

Formula

C50H46F2N2O8Ca

Formula Wt.

880.98

IUPAC Name

calcium;(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3, 5-dihydroxyhept-6-enoate

Solubility

DMSO to 51 mg/mL.

Appearance

Light Yellow Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P3576 MSDS PDF

Info Sheet

P3576 Info Sheet PDF

References

Tajiri K, Shimojo N, Sakai S, et al. Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice. Cardiovasc Drugs Ther. 2013 Oct;27(5):413-24. PMID: 23722419.

Ansari JA, Bhandari U, Haque SE, et al. Enhancement of antioxidant defense mechanism by pitavastatin and rosuvastatin on obesity-induced oxidative stress in Wistar rats. Toxicol Mech Methods. 2012 Jan;22(1):67-73. PMID: 21859367.

Abd El-Latif MI, Murota H, Terao M, et al. Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and low-density lipoprotein on proliferation and migration of keratinocytes. Br J Dermatol. 2010 Jul;163(1):128-37. PMID: 20163419.

Suzuki J, Koga N, Kosuge H, et al. Pitavastatin suppresses acute and chronic rejection in murine cardiac allografts. Transplantation. 2007 Apr 27;83(8):1093-7. PMID: 17452900.

Aoki T, Yamazaki H, Suzuki H, et al. Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia. Arzneimittelforschung. 2001;51(3):197-203. PMID: 11304935.

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