LKT Labs

Biochemicals for Life Science Research

Pituitary Adenylate Cyclase-activating Polypeptide-related Peptide, human

Pituitary Adenylate Cyclase-activating Polypeptide-related Peptide, human

Product ID P0010
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $99.80 In stock
1 mg $157.50 In stock
2.5 mg $315.00 In stock
Bulk Quote

Quicklinks

Description

Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates cAMP production in the anterior pituitary. PACAP and PACAP-related peptide (PRP) regulate immune function and display increases in expression when hosts are challenged with bacterial pathogens. PACAP and PRP also control expression of reproductive hormones such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Additionally, PACAP and PRP bind the PAC1 receptor and VPAC1/2 receptors. PACAP itself inhibits K+ amplitude of delayed rectifier K+ channels, exhibiting anti-apoptotic activity in cerebellar granule cells.

Product Info

Purity

≥95%
Formula

C139H229N41O42
Formula Wt.

3146.62
Synonym

PACAP-related peptide, PRP
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

P0010 MSDS PDF
Info Sheet

P0010 Info Sheet PDF

References

Nam BH, Moon JY, Kim YO, et al. Structural and functional characterization of pituitary adenylyl cyclase-activating polypeptide (PACAP)/PACAP-related peptide (PRP) and its receptor in olive flounder (Paralichthys olivaceus). Comp Biochem Physiol B Biochem Mol Biol. 2013 Jan;164(1):18-28. PMID: 23026070.

Tam JK, Lee LT, Cheng CH, et al. Discovery of a new reproductive hormone in teleosts: pituitary adenylate cyclase-activating polypeptide-related peptide (PRP). Gen Comp Endocrinol. 2011 Sep 15;173(3):405-10. PMID: 21703272.

Vaudry D, Falluel-Morel A, Bourgault S, et al. Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev. 2009 Sep;61(3):283-357. PMID: 19805477.

Mei YA, Vaudry D, Basille M, et al. PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP. Eur J Neurosci. 2004 Mar;19(6):1446-58. PMID: 15066141.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4440

    Allicin

    Organosulfur found in garlic, binds DNA; inward...

    ≥98%
  • S0381

    Sauvagine

    CRF-related peptide found in amphibians.

    ≥98%
  • A745817

    Asunaprevir

    Antiviral againt SARS-CoV-2

    ≥98%
  • T0109

    13-Acetyl-9-dihydrobaccatin-III

    Found in Taxus, starting material for synthesis...

    ≥98%
  • C1869

    Cerulenin

    Found in Cephalosporium; fatty acid synthase in...

    ≥98%
  • M4102

    MK-1775

    Wee1 inhibitor.

    ≥98%
  • G7346

    GSK-2636771

    p110β PI3K inhibitor.

    ≥98%
  • C1637

    Ceftriaxone Disodium Hemiheptahydrate

    β-lactam cephalosporin; penicillin binding pro...

    ≥98%
  • A6825

    L-Arginine

    Endogenous amino acid, also found in meat, dair...

    ≥98%
  • H1862

    Heptaplatin

    Pt-based DNA cross-linker.

    ≥98%
  • P3209

    Piceatannol

    Polyphenolic hydroxystilbene, resveratrol deri...

    ≥99%
  • E4902

    Emamectin B1 Benzoate

    Semi-synthetic avermectin; GABA potentiator.

    ≥80%
  • P3313

    Pidotimod

    Immunostimulator, adjuvant.

    ≥98%
  • G7440

    GSK-1120212

    MEK1/2 inhibitor.

    ≥98%
  • O6932

    Oridonin

    Diterpenoid found in Rabdosia rubescens; potent...

    ≥98%
  • G1721

    Gefitinib

    EGFR inhibitor.

    ≥98%
  • C6955

    Cromolyn Sodium

    Mast cell destabilizer; potential TRP antagonis...

    ≥99%
  • C0006

    Cabozantinib

    VEGFR2, c-Met, RET inhibitor.

    ≥98%
  • C0271

    Carfilzomib

    Epoxomicin analog; proteasome inhibitor.

    ≥98%
  • E6896

    Erysolin

    ITC found in cruciferous vegetables, analog of ...

    ≥97%