LKT Labs

Biochemicals for Life Science Research

Pituitary Adenylate Cyclase-activating Polypeptide-related Peptide, human

Pituitary Adenylate Cyclase-activating Polypeptide-related Peptide, human

Product ID P0010
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $99.80 In stock
1 mg $157.50 In stock
2.5 mg $315.00 In stock
Bulk Quote

Quicklinks

Description

Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates cAMP production in the anterior pituitary. PACAP and PACAP-related peptide (PRP) regulate immune function and display increases in expression when hosts are challenged with bacterial pathogens. PACAP and PRP also control expression of reproductive hormones such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Additionally, PACAP and PRP bind the PAC1 receptor and VPAC1/2 receptors. PACAP itself inhibits K+ amplitude of delayed rectifier K+ channels, exhibiting anti-apoptotic activity in cerebellar granule cells.

Product Info

Purity

≥95%
Formula

C139H229N41O42
Formula Wt.

3146.62
Synonym

PACAP-related peptide, PRP
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

P0010 MSDS PDF
Info Sheet

P0010 Info Sheet PDF

References

Nam BH, Moon JY, Kim YO, et al. Structural and functional characterization of pituitary adenylyl cyclase-activating polypeptide (PACAP)/PACAP-related peptide (PRP) and its receptor in olive flounder (Paralichthys olivaceus). Comp Biochem Physiol B Biochem Mol Biol. 2013 Jan;164(1):18-28. PMID: 23026070.

Tam JK, Lee LT, Cheng CH, et al. Discovery of a new reproductive hormone in teleosts: pituitary adenylate cyclase-activating polypeptide-related peptide (PRP). Gen Comp Endocrinol. 2011 Sep 15;173(3):405-10. PMID: 21703272.

Vaudry D, Falluel-Morel A, Bourgault S, et al. Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev. 2009 Sep;61(3):283-357. PMID: 19805477.

Mei YA, Vaudry D, Basille M, et al. PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP. Eur J Neurosci. 2004 Mar;19(6):1446-58. PMID: 15066141.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S6233

    Spiramycin Hexanedioate

    Macrolide; protein synthesis inhibitor.

    ≥90%
  • P1917

    Phenylethyl 3-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥97%
  • J766160

    JTE907

    Selective Cannabinoid receptor 2(CB2) inverse a...

    ≥98%
  • E5202

    Enalapril

    ACE inhibitor.

    ≥98%
  • Z0252

    Zanamivir

    Neuraminidase inhibitor.

    ≥98%
  • I7870

    Itraconazole

    Triazole; 14-α demethylase inhibitor, Smo modu...

    ≥98%
  • D3215

    Didymin

    Flavonoid glycoside found in citrus fruit.

    ≥98%
  • M1744

    Melittin

    Antimicrobial peptide found in Apis mellifera.<...

    ≥95%
  • S1605

    Secretin, human

    Endogenous peptide hormone, involved in water h...

    ≥95%
  • P0346

    Palosuran Hydrochloride

    Urotensin II receptor antagonist.
  • A2658

    Agomelatine

    Melatonin analog; MT1/2 agonist, 5-HT2C antagon...

    ≥98%
  • C104762

    CCT-245737

    CHK1 inhibitor.

    ≥98%
  • N1982

    Neuromedin U, rat

    Endogenous neuropeptide, involved in energy hom...

    ≥95%
  • C291342

    CHIR-99021

    GSK3 inhibitor.

    ≥98%
  • A0902

    N-Acetyl-S-(N′-phenylhexylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant; HDAC inhib...

    ≥98%
  • V1810

    Vecuronium Bromide

    Non-depolarizing NMJ blocker; nAChR antagonist....

    ≥98%
  • C1649

    β-Cembrenediol

    Diterpene found in Anisomeles.

    ≥99%
  • G8800

    GW-788388

    ALK5 (activin-like) antagonist.  
    ≥97%
  • T0109

    13-Acetyl-9-dihydrobaccatin-III

    Found in Taxus, starting material for synthesis...

    ≥98%
  • C3263

    Ciprofloxacin Hydrochloride Monohydrate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%