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PPQ-102

PPQ-102

Product ID P6264
Cas No. 931706-15-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $135.00 In stock
10 mg $245.10 In stock
25 mg $506.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PPQ-102 is a pyramido-pyrrolo-quinoxalinedione that inhibits the cystic fibrosis transmembrane conductance regulator (CFTR) channel. PPQ-102 exhibits nephroprotective and anti-fibrotic activities, decreasing the size of pre-formed kidney cysts in animal models of polycystic kidney disease.

Product Info

Cas No.

931706-15-9

Purity

≥98%

Formula

C26H22N4O3

Formula Wt.

438.49

Chemical Name

7,9-Dimethyl-6-(5-methyl-2-furyl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione

IUPAC Name

7,9-Dimethyl-6-(5-methyl-2-furyl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione

Solubility

5mg/mL in DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P6264 MSDS PDF

Info Sheet

P6264 Info Sheet PDF

References

Snyder DS, Tradtrantip L, Yao C, et al. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem. 2011 Aug 11;54(15):5468-77. PMID: 21707078.

Tradtrantip L, Sonawane ND, Namkung W, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22;52(20):6447-55. PMID: 19785436.

Custom Order

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