LKT Labs

Biochemicals for Life Science Research

Prednisolone Sodium Phosphate

Product ID P7012
Cas No. 125-02-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $137.90 In stock
10 g $358.40 In stock
25 g $661.50 In stock
5 g $220.50 In stock
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Description

Prednisolone is a derivative of cortisol and a metabolite of prednisone; it exhibits immunosuppressive and anti-inflammatory activities. Prednisolone activates glucocorticoid receptors and is clinically used to treat inflammatory and autoimmune disorders. In mononuclear cells from subjects with multiple sclerosis, prednisolone decreases expression of T-bet, IFNγ, and phosphorylated STAT1, decreasing lymphocyte apoptosis. Additionally, prednisolone delays the progression of Duchenne muscular dystrophy (DMD), altering muscle fiber types in vivo. This form of prednisolone is water soluble.

Product Info

Cas No.

125-02-0
Purity

≥98%
Formula

C21H27Na2O8P
Formula Wt.

484.39
Chemical Name

11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(disodium phosphate)
IUPAC Name

disodium;[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl] phosphate
Synonym

Hydeltrasol, Prednisolone 21-phosphate disodium

Solubility

Soluble in water (250 mg/ mL), methanol (77 mg/mL) and ethanol.
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P7012 MSDS PDF
Info Sheet

P7012 Info Sheet PDF

References

Frisullo G, Nociti V, Iorio R, et al. Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients. Clin Immunol. 2007 Sep;124(3):284-93. PMID: 17627892.

Fisher I, Abraham D, Bouri K, et al. Prednisolone-induced changes in dystrophic skeletal muscle. FASEB J. 2005 May;19(7):834-6. Erratum in: FASEB J. 2005 May;19(7):1 p following 836. Hoffmann, Eric P [corrected to Hoffman, Eric P]. PMID: 15734791.

Davis M, Williams R, Chakraborty J, et al. Prednisone or prednisolone for the treatment of chronic active hepatitis? A comparison of plasma availability. Br J Clin Pharmacol. 1978 Jun;5(6):501-5. PMID: 656293.

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