Pregnenolone

Name: Pregnenolone
SKU: P7023
Availability: InStock

Product ID P7023

Cas No. 145-13-1

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Pregnenolone is the endogenous precursor to all steroid hormones; it exhibits neuromodulatory, cognition enhancing, and antipsychotic activities. Pregnenolone decreases the negative symptoms of schizophrenia and increases attention and working memory performance in schizophrenic subjects. Pregnenolone sulfate acts as a positive allosteric NMDA receptor potentiator and a negative allosteric GABA-A receptor potentiator. Additionally, pregnenolone sulfate activates transient receptor potential melanostatin (TRPM3) channels, increasing Ca2+ influx and insulin secretion in islet cells.

Product Info

Cas No.	145-13-1
Purity	≥98%
Formula	C₂₁H₃₂O₂
Formula Wt.	316.48
Chemical Name	(3β)-3-Hydroxypregn-5-en-20-one
IUPAC Name	1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
Melting Point	193°C
Solubility	Sparingly soluble in water. Soluble in ethyl acetate (1:1), acetone (0.006g/mL) and ethanol (.010g/mL).
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	P7023 MSDS PDF
Info Sheet	P7023 Info Sheet PDF
Brochures	TRP Channel Modulator Flyer

References

Kostakis E, Smith C, Jang MK, et al. The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. Mol Pharmacol. 2013 Aug;84(2):261-74. PMID: 23716622.

Marx CE, Bradford DW, Hamer RM, et al. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience. 2011 Sep 15;191:78-90. PMID: 21756978.

Wagner TF, Loch S, Lambert S, et al. Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol. 2008 Dec;10(12):1421-30. PMID: 18978782.

Majewska MD, Mienville JM, Vicini S. Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons. Neurosci Lett. 1988 Aug 1;90(3):279-84. PMID: 3138576.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Pregnenolone

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Ribavirin

10-Deacetyltaxol C

2-Hydroxyflutamide

GLYX-13 Trifluoroacetate

Quinestrol

Isosorbide Mononitrate

NVP-LDE225 Diphosphate

Dopamine Hydrochloride

Rifampicin

Nicardipine

Estradiol

BMS-911543

Doxofylline

Ricobendazole

N-Acetyl-S-(N′-phenylthiocarbamoyl)-L-cysteine

Pipemidic Acid

3-tert-Butyl-5-Methoxy-1,2-quinone

LOXO-101

Galactosamine Hydrochloride

WHI-P131

Footer