LKT Labs

Biochemicals for Life Science Research

Pregnenolone

Pregnenolone

Product ID P7023
Cas No. 145-13-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $57.00 In stock
25 g $157.00 In stock
100 g $342.00 In stock
Bulk Quote

Quicklinks

Description

Pregnenolone is the endogenous precursor to all steroid hormones; it exhibits neuromodulatory, cognition enhancing, and antipsychotic activities. Pregnenolone decreases the negative symptoms of schizophrenia and increases attention and working memory performance in schizophrenic subjects. Pregnenolone sulfate acts as a positive allosteric NMDA receptor potentiator and a negative allosteric GABA-A receptor potentiator. Additionally, pregnenolone sulfate activates transient receptor potential melanostatin (TRPM3) channels, increasing Ca2+ influx and insulin secretion in islet cells.

Product Info

Cas No.

145-13-1
Purity

≥98%
Formula

C21H32O2
Formula Wt.

316.48
Chemical Name

(3β)-3-Hydroxypregn-5-en-20-one
IUPAC Name

1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
Melting Point

193°C
Solubility

Sparingly soluble in water. Soluble in ethyl acetate (1:1), acetone (0.006g/mL) and ethanol (.010g/mL).
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P7023 MSDS PDF
Info Sheet

P7023 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Kostakis E, Smith C, Jang MK, et al. The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. Mol Pharmacol. 2013 Aug;84(2):261-74. PMID: 23716622.

Marx CE, Bradford DW, Hamer RM, et al. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience. 2011 Sep 15;191:78-90. PMID: 21756978.

Wagner TF, Loch S, Lambert S, et al. Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol. 2008 Dec;10(12):1421-30. PMID: 18978782.

Majewska MD, Mienville JM, Vicini S. Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons. Neurosci Lett. 1988 Aug 1;90(3):279-84. PMID: 3138576.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • U682040

    URB597

    FAAH inhibitor.

    ≥98%
  • C5618

    Coelenterazine, natural

    Light-emitting luciferin analog found in aquati...

    ≥98%
  • A1333

    Adipokinetic Hormone II from Schistocera gregaria

    Neuropeptide found in Schistocera gregaria.

    ≥95%
  • B5874

    Bosutinib

    Src and Abl inhibitor.

    ≥98%
  • C2946

    Chlorambucil

    Nitrogen mustard, DNA alkylator.

    ≥99%
  • T564091

    β-Tocopherol

    Vitamin E component

    ≥98%
  • A5301

    Anacetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • N8662

    NVP-BGJ398

    FGFR inhibitor.

    ≥98%
  • K3352

    Kinetensin

    Peptide, neurotensin analog.

    ≥95%
  • D1768

    Dermaseptin I

    Cationic antimicrobial peptide, alters bacteria...

    ≥96%
  • P5712

    Podophyllotoxin

    Non-alkaloid lignan found in Podophyllum,deriva...

    ≥90%
  • T0107

    Xylosyltaxol C

    Taxane found in species of Taxus; potential mic...

    ≥90%
  • O4400

    Olanzapine

    AMPK activator, D1-4, 5-HT1A/2/3/6/7, M1-5 mACh...

    ≥99%
  • A4617

    Aloe Emodin

    Anthraquinone found in aloe; CTFR Cl- channel a...

    ≥98%
  • W317520

    WIN 55,212-2 Mesylate

    Non-selective cannabinoid receptor agonist.

    ≥98%
  • F5871

    N-formyl-Met-Leu-Phe-Lys

    Peptide, involved in neutrophil activation; FPR...

    ≥95%
  • P6901

    Pramipexole Dihydrochloride

    D2/3 agonist.

    ≥98%
  • T165133

    Tedizolid Phosphate

    Effective against gram-positive pathogens

    ≥98%
  • T3041

    Thienylpropyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • G7342

    GSK-2126458

    p110α PI3K and mTOR inhibitor.

    ≥99%