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Primaquine is an anti-parasitic compound that is used in the treatment of malaria. The antimalarial activity of primaquine stems from its ability to alter membrane permeability and to prevent formation of intracellular transport vesicles at the budding stage.
| Cas No. | 63-45-6 |
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| Purity | ≥98% (titration) |
| Formula | C15H21N3O • 2H3PO4 |
| Formula Wt. | 455.29 |
| Chemical Name | N4-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine diphosphate |
| IUPAC Name | 4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine;phosphoric acid |
| Synonym | Primaquine diphosphate |
| Melting Point | 197-198°C |
| Solubility | Soluble in water (66 mg/mL). |
| Appearance | Orange-red, crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Basso LG, Rodrigues RZ, Naal RM, et al. Effects of the antimalarial drug primaquine on the dynamic structure of lipid model membranes. Biochim Biophys Acta. 2011 Jan;1808(1):55-64. PMID: 20713019.
Hiebsch RR, Raub TJ, Wattenberg BW. Primaquine blocks transport by inhibiting the formation of functional transport vesicles. Studies in a cell-free assay of protein transport through the Golgi apparatus. J Biol Chem. 1991 Oct 25;266(30):20323-8. PMID: 1657920.