LKT Labs

Biochemicals for Life Science Research

Prostaglandin E1

Product ID P6956
Cas No. 745-65-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $40.80 In stock
5 mg $102.20 In stock
10 mg $143.20 In stock
50 mg $572.40 In stock
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Description

Prostaglandin E1 (PGE1) is an endogenous prostaglandin synthesized from linolenic acid. PGE1 is clinically used for its vasodilatory activity as a treatment for erectile dysfunction. PGE1 also exhibits nephroprotective and pro-angiogenic activities. PGE1 decreases small intestine mucosa lesions in animal models of intestinal ischemia/reperfusion. PGE1 also improves renal function in subject with renal dysfunction or renal failure. Additionally, PGE1 enhances VEGF production in animal models of ischemia.

Product Info

Cas No.

745-65-3
Purity

≥98%
Formula

C20H34O5
Formula Wt.

354.48
Chemical Name

(11a,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid
IUPAC Name

7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
Synonym

Alprostadil, PGE1, Caverject, Muse, Prostandin, Prostin VR
Melting Point

115-116°C
Solubility

Soluble in ethanol (5mg/mL) or acetone (10mg/mL).
Appearance

White Needle Crystal

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

P6956 MSDS PDF
Info Sheet

P6956 Info Sheet PDF

References

Hanchanale V, Eardley I. Alprostadil for the treatment of impotence. Expert Opin Pharmacother. 2014 Feb;15(3):421-8. PMID: 24369066.

Brasileiro JL, Inoye CM, Aydos RD, et al. Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1. Acta Cir Bras. 2013 Nov;28(11):767-73. PMID: 24316743.

Liu WJ, Zhang BC, Guo R, et al. Renoprotective effect of alprostadil in combination with statins in patients with mild to moderate renal failure undergoing coronary angiography. Chin Med J (Engl). 2013;126(18):3475-80. PMID: 24034093.

Inoue H, Aihara M, Tomioka M, et al. Specific enhancement of vascular endothelial growth factor (VEGF) production in ischemic region by alprostadil--potential therapeutic application in pharmaceutical regenerative medicine. J Pharmacol Sci. 2013;122(2):158-61. PMID: 23728380.

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