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Prostaglandin E2

Prostaglandin E2

Product ID P698583
Cas No. 363-24-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $106.40 In stock
10 mg $170.40 In stock
50 mg $606.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Prostaglandin E2 is the principal metabolic product of COX-2, an enzyme that produces prostaglandins in inflammatory and tumorigenic environments. Prostaglandin E2 is a well-known participant in tumorigenesis. It has been found that elevated levels of prostaglandin E2 is correlated with the metastatic potential of cancer cells. Prostaglandin E2 is used clinically in the induction of labor for pregnancies at or near term.

Product Info

Cas No.

363-24-6

Purity

≥98%

Formula

C20H32O5

Formula Wt.

352.47

Chemical Name

(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid

IUPAC Name

(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid

Synonym

Dinoprostone; PGE2; 363-24-6; Prostin E2; Prepidil 

Melting Point

67°C

Solubility

Water Solubility: 0.058 mg/mL

Appearance

White to off-white solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P698583 MSDS PDF

Info Sheet

P698583 Info Sheet PDF

References

Pun IH, Chan D, Chan SH, et al. Anti-cancer effects of a novel quinoline derivative 83b1 on human esophageal squamous cell carcinoma through down-regulation of COX-2 mRNA and PGE2. Cancer Res Treat. 2017 Jan;49(1):219-229. PMID: 27456944.

Greenhough A, Smartt H, Moore A, et al. The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis. 2009 Mar 1;30(3):377-386.

Zimmermann KC, Sarbia M, Weber AA, et al. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res. 1999 Jan 1;59(1):198-204. PMID: 9892207.

Morris M, Bolnga JW, Verave O, et al. Safety and effectiveness of oral misoprostol for induction of labour in a resource-limited setting: a dose escalation study. BMC Pregnancy Childbirth. 2017 Sep 8;17(1):298. PMID: 28886702.

Custom Order

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