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Prostaglandin E2 is the principal metabolic product of COX-2, an enzyme that produces prostaglandins in inflammatory and tumorigenic environments. Prostaglandin E2 is a well-known participant in tumorigenesis. It has been found that elevated levels of prostaglandin E2 is correlated with the metastatic potential of cancer cells. Prostaglandin E2 is used clinically in the induction of labor for pregnancies at or near term.
| Cas No. | 363-24-6 |
|---|---|
| Purity | ≥98% |
| Formula | C20H32O5 |
| Formula Wt. | 352.47 |
| Chemical Name | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid |
| IUPAC Name | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid |
| Synonym | Dinoprostone; PGE2; 363-24-6; Prostin E2; Prepidil |
| Melting Point | 67°C |
| Solubility | Water Solubility: 0.058 mg/mL |
| Appearance | White to off-white solid |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Pun IH, Chan D, Chan SH, et al. Anti-cancer effects of a novel quinoline derivative 83b1 on human esophageal squamous cell carcinoma through down-regulation of COX-2 mRNA and PGE2. Cancer Res Treat. 2017 Jan;49(1):219-229. PMID: 27456944.
Greenhough A, Smartt H, Moore A, et al. The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis. 2009 Mar 1;30(3):377-386.
Zimmermann KC, Sarbia M, Weber AA, et al. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res. 1999 Jan 1;59(1):198-204. PMID: 9892207.
Morris M, Bolnga JW, Verave O, et al. Safety and effectiveness of oral misoprostol for induction of labour in a resource-limited setting: a dose escalation study. BMC Pregnancy Childbirth. 2017 Sep 8;17(1):298. PMID: 28886702.