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Protocatechuic Aldehyde

Protocatechuic Aldehyde

Product ID P7058
Cas No. 139-85-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $92.00 In stock
25 g $173.70 In stock
100 g $459.60 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Protocatechuic aldehyde is a polyphenol found in many plants and foods; it exhibits anti-inflammatory, cardioprotective, anti-atherosclerotic, and hepatoprotective activities. In animal models of ischemia/reperfusion, protocatechuic aldehyde decreases levels of creatine kinase-MB, troponin-1, TNF-α, IL-6, intracellular adhesion molecule 1 (ICAM-1), and inhibitor of κB kinase (IKK) and prevents activation of NF-κB, decreasing infarct size. Additionally, protocatechuic aldehyde decreases activity of high-mobility group box 1 (HMGB1) protein, decreasing levels of myeloperoxidase and activation of NF-κB and preventing sepsis in animal models. This compound also decreases activation of caspase 3 in endothelial cells, preventing apoptosis. In animal models of liver fibrosis, protocatechuic aldehyde decreases levels of collagen, TGF-β, and connective transforming growth factor (CTGF).

Product Info

Cas No.

139-85-5

Purity

≥98%

Formula

C7H6O3

Formula Wt.

138.12

Chemical Name

3,4-Dihydroxybenzaldehyde

IUPAC Name

3,4-dihydroxybenzaldehyde

Synonym

Protocatechualdehyde, 3,4-Dihydroxybenzaldehyde

Melting Point

153°C

Solubility

6310 mg/L H2O

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P7058 MSDS PDF

Info Sheet

P7058 Info Sheet PDF

References

Wei G, Guan Y, Yin Y, et al. Anti-inflammatory effect of protocatechuic aldehyde on myocardial ischemia/reperfusion injury in vivo and in vitro. Inflammation. 2013 Jun;36(3):592-602. PMID: 23269534.

Xing YL, Zhou Z, Agula, et al. Protocatechuic aldehyde inhibits lipopolysaccharide-induced human umbilical vein endothelial cell apoptosis via regulation of caspase-3. Phytother Res. 2012 Sep;26(9):1334-41. PMID: 22298410.

Xu Y, Jiang WL, Zhang SP, et al. Protocatechuic aldehyde protects against experimental sepsis in vitro and in vivo. Basic Clin Pharmacol Toxicol. 2012 Apr;110(4):384-9. PMID: 22050905.

Custom Order

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