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Pseudoginsenoside F11

Pseudoginsenoside F11

Product ID P7318
Cas No. 69884-00-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $102.20 In stock
5 mg $245.30 In stock
10 mg $347.00 In stock
25 mg $714.70 In stock
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  • References
  • Description
  • Product Info
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Description

Pseudoginsenoside F11 is a saponin originally found in species of Panax (ginseng) that exhibits anti-inflammatory, anti-diabetic, neuroprotective, cognition enhancing, and antioxidative activities. Pseudoginsenoside F11 inhibits LPS-stimulated expression of ROS, NO, Prostaglandin E2 (PGE2), IL-1β, IL-6, TNF-α, toll-like receptor 4 (TLR4), and MyD88, and suppresses activation of Akt and NF-κB in vitro and in vivo. Additionally, pseudoginsenoside F11 acts as a PPARγ agonist, promoting adiponectin oligomerization and secretion. This compound also inhibits amyloid-β (Aβ)-induced learning and memory impairment in animal models of Alzheimer’s disease and improves 6OHDA-induced motor coordination and activity impairments and oxidative damage in animal models of Parkinson’s disease.

Product Info

Cas No.

69884-00-0

Purity

≥98%

Formula

C42H72O14

Formula Wt.

801.49

IUPAC Name

(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-2-[[(6S,10R,12S,14R,17S)-3,12-dihydroxy-17-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-2,4,4,10,14-pentamethyl-1,2,3,5,6,7,8,9,11,12,13,15,16,17-tetradecahydrocyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol

Synonym

(3β,6α,12β,24R)-20,24-Epoxy-3,12,25-trihydroxydammaran-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside, Ginsenoside A1

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P7318 MSDS PDF

Info Sheet

P7318 Info Sheet PDF

References

Wang X, Wang C, Wang J, et al. Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways. Neuropharmacology. 2014 Apr;79:642-56. PMID: 24467851.

Wu G, Yi J, Liu L, et al. Pseudoginsenoside F11, a Novel Partial PPAR γ Agonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes. PPAR Res. 2013;2013:701017. PMID: 24454336.

Wang JY, Yang JY, Wang F, et al. Neuroprotective effect of pseudoginsenoside-f11 on a rat model of Parkinson's disease induced by 6-hydroxydopamine. Evid Based Complement Alternat Med. 2013;2013:152798. PMID: 24386001.

Wang CM, Liu MY, Wang F, et al. Anti-amnesic effect of pseudoginsenoside-F11 in two mouse models of Alzheimer's disease. Pharmacol Biochem Behav. 2013 May;106:57-67. PMID: 23541491.

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