• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Purvalanol A

Purvalanol A

Product ID P8270
Cas No. 212844-53-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $152.00 In stock
5 mg $548.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Purvalanol A is a purine derivative anticancer compound that inhibits cyclin-dependent kinases (CDKs). Purvalanol A induces cell cycle arrest and apoptosis in breast cancer cells and is clinically used to increase efficacy of co-administered chemotherapeutics by inhibiting breast cancer resistance protein (ABCG2) transport. In adipose-derived stem cells, purvalanol A inhibits CDK1/Cdc2 and CDK2/cyclin E, altering differentiation potential. Purvalanol A also inhibits JAK2/STAT activation and RNA polymerase II activity in gastric adenocarcinoma cells. Additionally, this compound decreases human T-cell leukemia virus type 1 (HTLV-1) proliferation.

Product Info

Cas No.

212844-53-6

Purity

≥98%

Formula

C19H25ClN6O

Formula Wt.

388.90

Chemical Name

6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine

IUPAC Name

(2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3- methylbutan-1-ol

Synonym

NG-60, Purv

Solubility

Soluble in methylene chloride (50mg/mL), DMSO and methanol.

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P8270 MSDS PDF

Info Sheet

P8270 Info Sheet PDF

References

Obakan P, Arısan ED, Özfiliz P, et al. Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells. Mol Biol Rep. 2014 Jan;41(1):145-54. PMID: 24190492.

Hofman J, Ahmadimoghaddam D, Hahnova L, et al. Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone. Pharmacol Res. 2012 Mar;65(3):312-9. PMID: 22173067.

Park H, Cho JA, Lim EH, et al. Cell cycle regulators are critical for maintaining the differentiation potential and immaturity in adipogenesis of adipose-derived stem cells. Differentiation. 2011 Oct;82(3):136-43. PMID: 21764208.

Iizuka D, Ogura A, Kuwabara M, et al. Purvalanol A induces apoptosis and downregulation of antiapoptotic proteins through abrogation of phosphorylation of JAK2/STAT3 and RNA polymerase II. Anticancer Drugs. 2008 Jul;19(6):565-72. PMID: 18525315.

Agbottah E, Yeh WI, Berro R, et al. Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. AIDS Res Ther. 2008 Jun 10;5:12. PMID: 18544167.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T0003

    T2 Tetraol

    Trichothecene mycotoxin produced by Fusarium.

    ≥97%, TLC
  • T3096

    Thymosin α-1

    Endogenous peptide fragment, immunostimulant; ...

    ≥95%
  • P3456

    Pimobendan

    PDE3 inhibitor.

    ≥99%
  • C9876

    CYT-387

    JAK2 inhibitor.

    ≥98%
  • T176503

    Temsirolimus

    Analog of rapamycin.

    ≥98%
  • T698579

    Tropodithietic Acid

    Produced by various marine proteobacteria

    ≥99%
  • P1753

    Penicillamine

    Penicillin derivative, chelating agent; carboxy...

    ≥97%
  • D3322

    Diflunisal

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • N0123

    Naftopidil

    α1-adrenergic antagonist.

    ≥98%
  • A7669

    A-type Natriuretic Peptide (1-28), rat

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • F3454

    Fingolimod Hydrochloride

    Sphingosine 1-phosphate antagonist.

    ≥99%
  • T6832

    Triamcinolone Acetonide

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • I5992

    IOX2

    Prolyl hydroxylase inhibitor.

    ≥98%
  • L0249

    Laminin Peptide YIGSR-NH2

    Laminin-derived peptapeptide.

    ≥98%
  • P0013

    P7C3

    Aminopropyl carbazole, neuroprotective.

    ≥98%
  • D1761

    15-Acetyl-deoxynivalenol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%, TLC
  • A4924

    AMG-208

    c-MET and Ron inhibitor.

    ≥98%
  • C0172

    Carbimazole

    Methimazole prodrug; thyroid peroxidase inhibit...

    ≥98%
  • L589940

    LOXO-101

    Inhibitor of tropomyosin kinase receptors TRKA,...

    ≥99%
  • S1846

    Selumetinib

    MEK1/2 inhibitor.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only