Purvalanol A

Name: Purvalanol A
SKU: P8270
Availability: InStock

Product ID P8270

Cas No. 212844-53-6

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Purvalanol A is a purine derivative anticancer compound that inhibits cyclin-dependent kinases (CDKs). Purvalanol A induces cell cycle arrest and apoptosis in breast cancer cells and is clinically used to increase efficacy of co-administered chemotherapeutics by inhibiting breast cancer resistance protein (ABCG2) transport. In adipose-derived stem cells, purvalanol A inhibits CDK1/Cdc2 and CDK2/cyclin E, altering differentiation potential. Purvalanol A also inhibits JAK2/STAT activation and RNA polymerase II activity in gastric adenocarcinoma cells. Additionally, this compound decreases human T-cell leukemia virus type 1 (HTLV-1) proliferation.

Product Info

Cas No.	212844-53-6
Purity	≥98%
Formula	C₁₉H₂₅ClN₆O
Formula Wt.	388.90
Chemical Name	6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine
IUPAC Name	(2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3- methylbutan-1-ol
Synonym	NG-60, Purv
Solubility	Soluble in methylene chloride (50mg/mL), DMSO and methanol.
Appearance	Yellow Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	P8270 MSDS PDF
Info Sheet	P8270 Info Sheet PDF

References

Obakan P, Arısan ED, Özfiliz P, et al. Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells. Mol Biol Rep. 2014 Jan;41(1):145-54. PMID: 24190492.

Hofman J, Ahmadimoghaddam D, Hahnova L, et al. Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone. Pharmacol Res. 2012 Mar;65(3):312-9. PMID: 22173067.

Park H, Cho JA, Lim EH, et al. Cell cycle regulators are critical for maintaining the differentiation potential and immaturity in adipogenesis of adipose-derived stem cells. Differentiation. 2011 Oct;82(3):136-43. PMID: 21764208.

Iizuka D, Ogura A, Kuwabara M, et al. Purvalanol A induces apoptosis and downregulation of antiapoptotic proteins through abrogation of phosphorylation of JAK2/STAT3 and RNA polymerase II. Anticancer Drugs. 2008 Jul;19(6):565-72. PMID: 18525315.

Agbottah E, Yeh WI, Berro R, et al. Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. AIDS Res Ther. 2008 Jun 10;5:12. PMID: 18544167.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Purvalanol A

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Vatalanib Dihydrochloride

DMXAA

Calcitonin, human

1-Isothiocyanato-8-(methylsulfonyl)-octane

Isatin

Daptomycin

Cridanimod

LY-3295668

Lofexidine Hydrochloride

Granisetron Hydrochloride

Sedanolide

alpha-Galactosylceramide

CO-1686

2,5-Di-tert-butyl-4-hydroxyanisole

1-Isothiocyanato-9-(methylsulfenyl)-nonane

Hesperetin

Lycopene

Veliparib

PD-184352

Patulin

Footer