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Quinestrol

Quinestrol

Product ID Q8135
Cas No. 152-43-2
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $68.10 In stock
250 mg $136.20 In stock
1 g $388.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Quinestrol is a synthetic estrogen homolog that exhibits anti-fertility and contraceptive activities. Quinestrol is an ER agonist and is also used in HRT. Quinestrol is displays clinical benefit in improving symptoms of postmenopausal syndrome. In males, quinestrol decreases the weight of the testis, epididymis, seminal vesicle, and prostate, decreases sperm count, and decreases levels of testosterone, lutropin, and follitropin. In females, quinestrol decreases levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), increases levels of progesterone and estradiol, and alters estrogen receptor expression. Quinestrol increases oxidative stress by decreasing activity of superoxide dismutase (SOD) and glutathione peroxidase and increasing levels of NO and malondialdehyde. In other animal models, this compound inhibits investigative reproductive behavior.

Product Info

Cas No.

152-43-2

Purity

≥98%

Formula

C25H32O2

Formula Wt.

364.52

IUPAC Name

(8R,9S,13S,14S,17R)-3-cyclopentyloxy-17-ethynyl-13-methyl-7,8,9,11,12, 14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol

Synonym

Eston, Estrovis, Plestrovis

Melting Point

107-108°C

Appearance

White or practically white, odorless

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

Q8135 MSDS PDF

Info Sheet

Q8135 Info Sheet PDF

References

Li J, Wang H, Zhang J, et al. Abnormal secretion of reproductive hormones and antioxidant status involved in quinestrol-induced reproductive toxicity in adult male rat. Tissue Cell. 2013 Oct 1. pii: S0040-8166(13)00081-5. PMID: 24183492.

Liu Q, Qin J, Chen Q, et al. Fertility control of Rattus nitidus using quinestrol: effects on reproductive organs and social behavior. Integr Zool. 2013 Apr;8 Suppl 1:9-17. PMID: 23621467.

Lv X, Guo Y, Shi D. Effects of quinestrol on reproductive hormone expression, secretion, and receptor levels in female Mongolian gerbils (Meriones unguiculatus). Theriogenology. 2012 Apr 1;77(6):1223-31. PMID: 22284225.

Jaschevatzky OE, Anderman S, Shalit A, et al. The treatment of postmenopausal syndrome by monthly oral doses of quinestrol. Acta Obstet Gynecol Scand. 1979;58(2):175-8. PMID: 452871.

Custom Order

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