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Ramatroban

Ramatroban

Product ID R0248
Cas No. 116649-85-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $153.10 In stock
10 mg $265.30 In stock
25 mg $633.00 In stock
100 mg $1,837.50 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ramatroban is a thromboxane A2 (TxA2) receptor inhibitor that exhibits anti-allergic and anti-inflammatory properties. Ramatroban also competitively inhibits chemoattractant receptor-homologous molecule on Th2 cells (CRTH2), a relatively new prostaglandin D2 (PGD2) receptor. Ramatroban decreases expression of inflammatory mediator IL-16 and also inhibits expression of adhesion molecules and prevents infiltration of immune cells.

Product Info

Cas No.

116649-85-5

Purity

≥98%

Formula

C21H21FN2O4S

Formula Wt.

416.47

Chemical Name

3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid

IUPAC Name

3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3, 4-tetrahydrocarbazol-9-yl]propanoic acid

Synonym

Baynas, BAY u3405

Solubility

Ethanol (30 mg/ml), DMSO (30 mg/ml), DMF (30 mg/ml)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R0248 MSDS PDF

Info Sheet

R0248 Info Sheet PDF

References

Suzuki Y, Inoue T, Yamamoto A, et al. Prophylactic effects of the histamine H1 receptor antagonist epinastine and the dual thromboxane A2 receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells antagonist ramatroban on allergic rhinitis model in mice. Biol Pharm Bull. 2011;34(4):507-10. PMID: 21467637.

Akiyama K, Karaki M, Kobayshi R, et al. IL-16 variability and modulation by antiallergic drugs in a murine experimental allergic rhinitis model. Int Arch Allergy Immunol. 2009;149(4):315-22. PMID: 19295235.

Sugimoto H, Shichijo M, Okano M, et al. CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7. PMID: 16256979.

Shiraishi Y, Asano K, Nakajima T, et al. Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. J Pharmacol Exp Ther. 2005 Mar;312(3):954-60. PMID: 15528449.

Ishizuka T, Matsui T, Okamoto Y, et al. Ramatroban (BAY u 3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor. Cardiovasc Drug Rev. 2004 Summer;22(2):71-90. PMID: 15179446.

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