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Ramelteon is a melatonin MT1/2 receptor agonist used clinically to treat insomnia. Ramelteon displays hypnotic activity and may be immunostimulatory as well. In animal models, ramelteon decreases wakefulness and increases slow-wave and rapid eye movement (REM) sleep.
| Cas No. | 196597-26-9 |
|---|---|
| Purity | ≥99% |
| Formula | C16H21NO2 |
| Formula Wt. | 259.34 |
| Chemical Name | (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b] furan-8-yl)ethyl]propionamide |
| IUPAC Name | N-[2-[(8S)-2,6,7, 8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide |
| Melting Point | 113-116°C |
| Solubility | Soluble in water (<1.2 mg/ml), ethanol (≥50 mg/ml), DMSO (≥50 mg/ml), DMF, and methanol |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Fourman LT, Robert Meyer B. Autoimmune hepatitis in association with ramelteon. J Clin Gastroenterol. 2013 Aug;47(7):651-4. PMID: 23632362.
Zammit GK. Ramelteon: a novel hypnotic indicated for the treatment of insomnia. Psychiatry (Edgmont). 2007 Sep;4(9):36-42. PMID: 20532119.
Miyamoto M, Nishikawa H, Doken Y, et al. The sleep-promoting action of ramelteon (TAK-375) in freely moving cats. Sleep. 2004 Nov 1;27(7):1319-25. PMID: 15586784.