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Ranolazine Dihydrochloride

Ranolazine Dihydrochloride

Product ID R0154
Cas No. 95635-56-6
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $97.70 In stock
100 mg $180.30 In stock
500 mg $578.40 In stock
1 g $976.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ranolazine exhibits anti-anginal, anti-arrhythmic, and cardioprotective activities; it is clinically used to treat angina pectoris. Ranolazine inhibits the late Na+ current (Nav1.7 and Nav1.7 channels) and subsequent intracellular Ca2+ accumulation. In hypertensive rats, ranolazine decreases end diastolic pressure, improving diastolic function and decreasing free Ca2+ levels. In other animal models, ranolazine inhibits induction of atrial flutter and atrial fibrillation.

Product Info

Cas No.

95635-56-6

Purity

≥98%

Formula

C24H33N3O4 • 2HCl

Formula Wt.

500.47

Chemical Name

N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride

IUPAC Name

N-(2, 6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin- 1-yl]acetamide;dihydrochloride

Synonym

RS-43285

Melting Point

164-166°C

Solubility

Soluble in water.

Appearance

A White or Almost White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R0154 MSDS PDF

Info Sheet

R0154 Info Sheet PDF

References

Sobky S, Fawzy I, Ahmed M, et al. Drug repurposing of argatroban, glimepiride, and ranolazine shows anti-SARS-CoV-2 activity via diverse mechanisms. Heliyon. 2025 Jan 10;11(3):e41894. PMID: 39968139.

Tocchetti CG, Carpi A, Coppola C, et al. Ranolazine protects from doxorubicin-induced oxidative stress and cardiac dysfunction. Eur J Heart Fail. 2014 Jan 6. [Epub ahead of print]. PMID: 24464789.

Aldakkak M, Stowe DF, Camara AK. Safety and Efficacy of Ranolazine for the Treatment of Chronic Angina Pectoris. Clin Med Insights Ther. 2013 Jan 15;2013(5):1-14. PMID: 24574825.

Aidonidis I, Doulas K, Hatziefthimiou A, et al. Ranolazine-induced postrepolarization refractoriness suppresses induction of atrial flutter and fibrillation in anesthetized rabbits. J Cardiovasc Pharmacol Ther. 2013 Jan;18(1):94-101. PMID: 22872232.

Custom Order

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