• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Reversine

Reversine

Product ID R1885
Cas No. 656820-32-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $102.30 Please Inquire
5 mg $216.20 Please Inquire
10 mg $379.70 Please Inquire
25 mg $810.20 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Reversine is a purine analog that reverses or induces differentiation. Reversine displays anticancer chemotherapeutic and anti-metastatic activities; it transforms preadipocytes into mesenchymal stem cells, induces autophagy in thyroid cancer cells, and downregulates expression of miR-133a miRNA. This compound induces apoptosis and cell death in breast cancer cells. In animal models of cancer, reversine inhibits focal adhesion disassembly, decreases cell motility and invasion, and prevents tumor metastasis.

Product Info

Cas No.

656820-32-5

Purity

≥98%

Formula

C21H27N7O

Formula Wt.

393.50

IUPAC Name

N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-3H-purine-2,6-diamine

Solubility

DMSO: 7mg/mL water: insoluble

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

R1885 MSDS PDF

Info Sheet

R1885 Info Sheet PDF

References

Kuo CH, Lu YC, Tseng YS, et al. Reversine induces cell cycle arrest, polyploidy, and apoptosis in human breast cancer cells. Breast Cancer. 2014 May;21(3):358-69. PMID: 22926505.

Park JG, Lee DH, Moon YS, et al. Reversine increases the plasticity of lineage-committed preadipocytes to osteogenesis by inhibiting adipogenesis through induction of TGF-β pathway in vitro. Biochem Biophys Res Commun. 2014 Mar 28;446(1):30-6. PMID: 24548409.

Kim M, Yi SA, Lee H, et al. Reversine induces multipotency of lineage-committed cells through epigenetic silencing of miR-133a. Biochem Biophys Res Commun. 2014 Feb 28;445(1):255-62. PMID: 24513286.

Bijian K, Lougheed C, Su J, et al. Targeting focal adhesion turnover in invasive breast cancer cells by the purine derivative reversine. Br J Cancer. 2013 Nov 26;109(11):2810-8. PMID: 24169345.

Lu CH, Liu YW, Hua SC, et al. Autophagy induction of reversine on human follicular thyroid cancer cells. Biomed Pharmacother. 2012 Dec;66(8):642-7. PMID: 23089471.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C179603

    CEP-37440 Hydrochloride

    Inhibitor of FAK and ALK.

    ≥99%
  • N3450

    Nimesulide

    NSAID; COX-2 inhibitor.

    ≥98%
  • L302690

    LHRH Acetate Salt

    Endogenous peptide hormone, involved in secreti...

    ≥95%
  • F4480

    5-Fluorouracil

    Pyrimidine analog; inhibits thymidylate synthas...

    ≥98%
  • D0006

    Dacomitinib Monohydrate

    EGFR inhibitor.

    ≥99%
  • L960004

    LY-404187

    Selective positive allosteric modulator of AMPA...

    ≥98%
  • A0802

    Acarbose

    α-glucosidase inhibitor.

    ≥98%
  • B8261

    Bupivacaine

    BK/SK, Kv1, Kv3, TASK-2 K+ channel blocker, vol...

    ≥99%
  • C224760

    CFT-7455

    Degrader of IKZF1/3

    ≥98%
  • I0801

    IC261

    Casein kinase 1 inhibitor.

    ≥98%
  • M184774

    5-(Methylsulfinyl)pentyl Nitrile

    Synthetic compound related to sulforaphane.

    ≥98%
  • B1876

    Betamethasone

    Steroid; glucocorticoid agonist.

    ≥98%
  • F1655

    Fenoprofen Calcium Dihydrate

    NSAID; COX-1/2 inhibitor.

    ≥97%
  • M2400

    MG-132

    Proteasome inhibitor.

    ≥98%
  • F5874

    Fosfomycin Calcium

    MurA and isopentenyl mevalonate kinase inhibito...

    ≥95%
  • W2933

    WHI-P131

    JAK3 and EGFR inhibitor.

    ≥99%
  • M5727

    Moguisteine

    Potential ATP-sensitive K+ channel blocker, pot...

    ≥98%
  • A4854

    β-Amyloid Peptide (1-42), rat

    Endogenous APP peptide cleavage product, primar...

    ≥95%
  • P0109

    P7C3A20

    Fluorinated aminopropyl carbazole, neuroprotect...

    ≥94%
  • H1992

    Hexaconazole

    Triazole; demethylation inhibitor.

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only