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Palmatine Chloride Hydrate

Palmatine Chloride Hydrate

Product ID P0245
Cas No. 171869-95-7
Purity ≥96%
Product Unit SizeCostQuantityStock
1 g $61.10 In stock
5 g $183.60 In stock
10 g $255.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Palmatine is an isoquinoline alkaloid found in Corydalis, Phellodendron, Enantia, and other plants. Palmatine exhibits sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities. Palmatine binds hemoglobin and DNA at AT base pairs. In animal models, palmatine decreases locomotor activity and levels of dopamine, 5-HT, and homovanillic acid. In prostate cancer cells, palmatine decreases growth and invasion as well as activation of FLIP and NF-κB. Palmatine also decreases immobility time in animals undergoing the forced swim test and tail suspension test. In separate animal models, this compound acts as a radical scavenger, inhibits Helicobacter growth, and decreases gastric ulcer formation.

Product Info

Cas No.

171869-95-7

Purity

≥96%

Formula

C21H22ClNO4 • xH2O

Formula Wt.

387.86

Chemical Name

5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium chloride hydrate

IUPAC Name

2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride;hydrate

Synonym

Berbericinine, Palmatin

Melting Point

206-207°C(dec)

Solubility

Soluble in hot water and alcohol.

Appearance

Yellow needle crystal, powder, odorless

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P0245 MSDS PDF

Info Sheet

P0245 Info Sheet PDF

References

Hambright HG, Batth IS, Xie J, et al. Palmatine inhibits growth and invasion in prostate cancer cell: Potential role for rpS6/NFκB/FLIP. Mol Carcinog. 2014 Jul 7. [Epub ahead of print]. PMID: 25043857.

Liu B, Yan X, Cao S, et al. Studies on the interaction of palmatine hydrochloride with bovine hemoglobin. Luminescence. 2014 May;29(3):211-8. PMID: 23696111.

Jung J, Choi JS, Jeong CS. Inhibitory Activities of Palmatine from Coptis chinensis Against Helicobactor pylori and Gastric Damage. Toxicol Res. 2014 Mar;30(1):45-8. PMID: 24795799.

Dhingra D, Bhankher A. Behavioral and biochemical evidences for antidepressant-like activity of palmatine in mice subjected to chronic unpredictable mild stress. Pharmacol Rep. 2014 Feb;66(1):1-9. PMID: 24905299.

Bhadra K, Maiti M, Kumar GS. Molecular recognition of DNA by small molecules: AT base pair specific intercalative binding of cytotoxic plant alkaloid palmatine. Biochim Biophys Acta. 2007 Jul;1770(7):1071-80. PMID: 17434677.

Hsieh MT, Su SH, Tsai HY, et al. Effects of palmatine on motor activity and the concentration of central monoamines and its metabolites in rats. Jpn J Pharmacol. 1993 Jan;61(1):1-5. PMID: 7679763.

Custom Order

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