• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Rifampicin

Rifampicin

Product ID R3220
Cas No. 13292-46-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $74.40 In stock
5 g $247.30 In stock
25 g $927.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Rifampicin is an ansamycin antibiotic that exhibits antibacterial, neuroprotective, and anti-inflammatory activities. Rifampicin inhibits bacterial DNA-dependent RNA polymerase, preventing formation of the initiation complex in transcription and suppressing RNA synthesis; it is active against Mycobacterium and is clinically used to treat tuberculosis. In microglia, rifampicin decreases expression of the 26S protease regulatory subunit (MSS1), suppressing inflammatory cytokine release. Additionally, rifampicin upregulates expression of LRP1 and P-gp at the blood brain barrier, increasing clearance of amyloid-β (Aβ) and displaying potential efficacy in the treatment of Alzheimer’s disease.

Product Info

Cas No.

13292-46-1

Purity

≥98%

Formula

C43H58N4O12

Formula Wt.

822.94

Chemical Name

3-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin

IUPAC Name

[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate

Synonym

Rifampin, Abrifam, Eremfat, Rifa, Rifaldin, Rifoldin

Melting Point

183-188°C (dec)

Solubility

Soluble in DMSO ethyl acetate, methanol and THF. Slightly soluble in water, acetone, and carbon terachloride, chloroform. Water pH 4.3 to 1.3 mg/mL; Water pH 7.3 to 2.5 mg/mL.

Appearance

Red Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R3220 MSDS PDF

Info Sheet

R3220 Info Sheet PDF

References

Sharma SK, Sharma A, Kadhiravan T, et al. Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB. Cochrane Database Syst Rev. 2013 Jul 5;7:CD007545. PMID: 23828580.

Bi W, Jing X, Zhu L, et al. Inhibition of 26S protease regulatory subunit 7 (MSS1) suppresses neuroinflammation. PLoS One. 2012;7(5):e36142. PMID: 22629310.

Qosa H, Abuznait AH, Hill RA, et al. Enhanced brain amyloid-β clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease. J Alzheimers Dis. 2012;31(1):151-65. PMID: 22504320.

Campbell EA, Korzheva N, Mustaev A, et al. Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell. 2001 Mar 23;104(6):901-12. PMID: 11290327.

https://www.genengnews.com/topics/drug-discovery/drug-repositioning/antibiotic-dietary-supplement-combo-improves-cognition-in-mouse-dementia-models/

Goetz J, Keyssner V, Hanses F, et al. Animal experimental investigation on the efficacy of antibiotic therapy with linezolid, vancomycin, cotrimoxazole, and rifampin in treatment of periprosthetic knee joint infections by MSRA. Bone Joint Res. 2022 Mar;11(3):143-151. PMID: 35227086.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M324081

    Micafungin Sodium

    Echinocandin antifungal

    ≥98%
  • A4805

    Amastatin Hydrochloride Hydrate

    Aminopeptidase inhibitor.

    ≥98%
  • G2868

    Ghrelin, human

    Endogenous peptide hormone, involved in feeding...

    ≥98%
  • B5000

    BMS-911543

    JAK2 inhibitor.

    ≥99%
  • S8344

    R,S-(±)-Sulpiride

    GHB agonist, D2/3 antagonist.

    ≥98%
  • F3209

    Fibronectin-Binding Protein

    Peptide, binds fibronectin.

    ≥95%
  • D3448

    Dimethyl Fumarate

    Fumaric acid methyl ester; nAChR agonist, indir...

    ≥98%
  • F4682

    Fluconazole

    Triazole; 14-α demethylase inhibitor.

    ≥98%
  • A0968

    Adrenocorticotropic Hormone (1-24), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • T2935

    Thiamphenicol

    Chloramphenicol derivative; protein translation...

    ≥98%
  • T176503

    Temsirolimus

    Analog of rapamycin.

    ≥98%
  • T3585

    Tivozanib

    VEGFR1/2/3, c-Kit, PDGFR inhibitor.

    ≥98%
  • D3330

    Dihydrotanshinone

    Found in Salvia; fatty acid synthase and AChE i...

    ≥90%
  • R1777

    9-cis-Retinoic Acid

    Vitamin A derivative; RAR and RXR agonist.

    ≥99%
  • G3552

    20S-Ginsenoside Rg3

    Triterpene saponin found in Panax; Kv7.1 K+ cha...

    ≥98%
  • E0003

    E64-d

    Cathepsin inhibitor.

    ≥97%
  • B1955

    Benztropine Mesylate

    DAT inhibitor.

    ≥99%
  • A4675

    Alternariol

    Mycotoxin produced by Alternaria; topoisomerase...

    ≥98%
  • F4881

    Flumequine Sodium

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • A0822

    N-Acetyl-S-(N-methylsulfinylbutylthiocarbamoyl)-L-cysteine

    Sulforaphane-cysteine conjugate.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only