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Rifaximin is a rifampicin derivative with weaker absorption kinetics; it inhibits DNA-dependent RNA polymerase. Rifaximin is an ansamycin antibacterial compound that is clinically used to treat small intestinal bacterial overgrowth in subjects with inflammatory bowel syndrome (IBS).
| Cas No. | 80621-81-4 |
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| Purity | ≥98% |
| Formula | C43H51N3O11 |
| Formula Wt. | 785.88 |
| Chemical Name | [2S-(2R*,16Z,18E,20R*,21R*,22S*,23S*,24S*,25R*,26S*,27R*,28E)]-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7- [epoxypentadeca(1,11,13)trienimino]-benzofuro[4,5-e]- pyridol[1,2-a]benzimidazole-1,15(2H)-dione |
| IUPAC Name | [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1(35),2,4,9,19,21,25(36),26(34),28,30,32-undecaen-13-yl] acetate |
| Synonym | Rifacol, XIFAXAN, Fatroximin, Normix, Rifacol |
| Melting Point | 200-205°C (dec) |
| Solubility | Soluble in alcohols, ethyl acetate, chloroform or toluene. |
| Appearance | A Red Orange Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Huhulescu S, Sagel U, Fiedler A, et al. Rifaximin disc diffusion test for in vitro susceptibility testing of Clostridium difficile. J Med Microbiol. 2011 Aug;60(Pt 8):1206-12. PMID: 21292853.
Majewski M, McCallum RW. Results of small intestinal bacterial overgrowth testing in irritable bowel syndrome patients: clinical profiles and effects of antibiotic trial. Adv Med Sci. 2007;52:139-42. PMID: 18217406.