Description
Risedronate is a bisphosphonate that exhibits anti-osteoporotic, anti-resorptive, anti-parasitic, and antimalarial activities. Risedronate inhibits bone marrow adipogenesis, decreases activity of mTORC1, and suppresses activation of NF-κB in vitro. In animal models, risedronate induces apoptosis in osteoclasts, upregulates expression of Bim, increases bone mineral density, and inhibits bone resorption. Additionally, risedronate inhibits Plasmodium survival in vivo by inhibiting transfer of farnesyl pyrophosphate.