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S-(−)-Sulpiride

Product ID S8345
Cas No. 23672-07-3
Purity ≥99%
Product Unit SizeCostQuantityStock
1 g $51.20 In stock
5 g $100.30 In stock
10 g $186.90 In stock
25 g $329.20 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Sulpiride is an antipsychotic that functions as an antagonist at D2/3 receptors and also upregulates and activates the GHB receptor. In vivo, sulpiride ameliorates increased impulsivity and attentional impairment in PFC-lesioned models of schizophrenia. Additionally, because dopamine inhibits prolactin release, sulpiride’s inhibition of dopamine results in increased concentrations of prolactin as well as melanocyte-stimulating hormone.

Product Info

Cas No.

23672-07-3

Purity

≥99%

Formula

C15H23N3O4S

Formula Wt.

341.43

IUPAC Name

N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide

Melting Point

178-180°C

Solubility

Soluble in DMF, DMSO (69 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (10 mM). 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL 0.1 M HCl: soluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

S8345 MSDS PDF

Info Sheet

S8345 Info Sheet PDF

References

Valencia NA, Thompson DL Jr, Mitcham PB. Changes in plasma melanocyte-stimulating hormone, ACTH, prolactin, GH, LH, FSH, and thyroid-stimulating hormone in response to injection of sulpiride, thyrotropin-releasing hormone, or vehicle in insulin-sensitive and -insensitive mares. Domest Anim Endocrinol. 2013 May;44(4):204-12. PMID: 23571008.

Pezze MA, Dalley JW, Robbins TW. Remediation of attentional dysfunction in rats with lesions of the medial prefrontal cortex by intra-accumbens administration of the dopamine D(2/3) receptor antagonist sulpiride. Psychopharmacology (Berl). 2009 Jan;202(1-3):307-13. PMID: 18985321.

Ratomponirina C, Gobaille S, Hodé Y, et al. Sulpiride, but not haloperidol, up-regulates gamma-hydroxybutyrate receptors in vivo and in cultured cells. Eur J Pharmacol. 1998 Apr 10;346(2-3):331-7. PMID: 9862377.

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