Description
SAG is a Smoothened agonist primarily used in research models to study Hedgehog signaling pathways. In vitro, SAG stimulates osteoblastic differentiation of mesenchymal stem cells and enhances proliferation of pulmonary arterial smooth muscle cells. SAG also increases expression of Patched and efflux of cholesterol. In vivo, this compound exhibits neuroprotective activity, preventing glucocorticoid-induced neurotoxicity.