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Saikosaponin A

Saikosaponin A

Product ID S0132
Cas No. 20736-09-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $388.80 In stock
5 mg $816.70 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Saikosaponin A is a triterpene saponin found in Bupleurum that exhibits anti-inflammatory, analgesic, neuromodulatory, anticancer, and immunosuppressive activities. Saikosaponin A decreases production of TNF-α, IL-1β, and IL-2 and increases mechanical withdrawal thresholds and thermal withdrawal thresholds in animal models of chronic constructive injury. Saikosaponin A also decreases self-administration of cocaine and morphine. In colon carcinoma cells, saikosaponin A causes activation of caspases 2, 3, 8, and 9 and PARP, induces apoptosis, and decreases expression of Bcl-2 and XIAP. Additionally, this compound inhibits the proliferation and activation of ConA-treated T cells, inducing G0/G1 phase cell cycle arrest and decreasing expression of TNF-α, IL-2, and IFN-γ.

Product Info

Cas No.

20736-09-8

Purity

≥98%

Formula

C42H68O13

Formula Wt.

780.98

IUPAC Name

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-3,5-dihydroxy-2-[[(1S,2S,4S,5R,8R,9R,10S,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracos-15-en-10-yl]oxy]-6-methyloxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

Melting Point

225-232°C

Solubility

Soluble in DMSO.

Appearance

White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S0132 MSDS PDF

Info Sheet

S0132 Info Sheet PDF

References

Zhou X, Cheng H, Xu D, et al. Attenuation of Neuropathic Pain by Saikosaponin a in a Rat Model of Chronic Constriction Injury. Neurochem Res. 2014 Aug 9. [Epub ahead of print]. PMID: 25107300.

Yoon SS, Seo JW, Ann SH, et al. Effects of saikosaponin A on cocaine self-administration in rats. Neurosci Lett. 2013 Oct 25;555:198-202. PMID: 24076136.

Kim BM, Hong SH. Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines. Apoptosis. 2011 Feb;16(2):184-97. PMID: 21107704.

Sun Y, Cai TT, Zhou XB, et al. Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and induction of apoptosis. Int Immunopharmacol. 2009 Jul;9(7-8):978-83. PMID: 19375524.

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