• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
SB-203580

SB-203580

Product ID S0500
Cas No. 152121-47-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $82.00 In stock
25 mg $284.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SB-203580 is an inhibitor of p38 MAPK that exhibits immunostimulatory, anticancer, and anti-fibrotic activities. In peripheral blood mononuclear cells, SB-203580 increases secretion of IFN-γ. In lung epithelial cells, SB-203580 inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT). Additionally, SB-203580 inhibits proliferation in glioma cells and decreases angiotensin II- and TGF-β1-induced expression of GTGF and fibronectin in other cellular models.

Product Info

Cas No.

152121-47-6

Purity

≥98%

Formula

C21H16FN3OS

Formula Wt.

377.43

Chemical Name

4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

IUPAC Name

4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

Synonym

SB203580; SB 203580

Solubility

DMSO 43 mg/mL (113.92 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S0500 MSDS PDF

Info Sheet

S0500 Info Sheet PDF

References

Kühnöl C, Herbarth M, Föll J, et al. CD137 stimulation and p38 MAPK inhibition improve reactivity in an in vitro model of glioblastoma immunotherapy. Cancer Immunol Immunother. 2013 Dec;62(12):1797-809. PMID: 24129764.

Chen HH, Zhou XL, Shi YL, et al. Roles of p38 MAPK and JNK in TGF-β1-induced human alveolar epithelial to mesenchymal transition. Arch Med Res. 2013 Feb;44(2):93-8. PMID: 23376055.

Morales MG, Vazquez Y, Acuña MJ, et al. Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells. Int J Biochem Cell Biol. 2012 Nov;44(11):1993-2002. PMID: 22964022.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L186858

    Levomefolic acid

    Folic acid derivative

    ≥98%
  • T4400

    TL-32711

    Smac mimetic; IAP inhibitor.

    ≥98%
  • B349921

    BIX-01294

    Specific inhibitor of histone methyltransferase...

    ≥99%
  • M2077

    1-Methoxy-5-methylphenazinium Methyl Sulfate

    Electron carrier used to study dehydrogenase el...

    ≥98%
  • D9752

    Dynasore

    Dynamin inhibitor.

    ≥98%
  • M1444

    MDL 29951

    GPR17 agonist, NMDA and fructose 1,6-bisphospha...

    ≥98%
  • W2933

    WHI-P131

    JAK3 and EGFR inhibitor.

    ≥99%
  • R3477

    Ritodrine Hydrochloride

    Phenylethylamine; β2-adrenergic agonist, SK/BK...

    ≥98%
  • I7359

    1-Isothiocyanato-8-(methylsulfenyl)-octane

    ITC, erucin analog.

    ≥98%
  • M5756

    Montelukast Sodium

    CysLT1 antagonist.

    ≥98%
  • A724091

    Asciminib

    Allosteric inhibitor

    ≥98%
  • P8370

    Purmorphamine

    Hedgehog and Smo agonist.

    ≥98%
  • E5240

    Leu-Enkephalin

    Endogenous opioid peptide; δOR and μOR agonis...

    ≥95%
  • W0273

    R-(+)-Warfarin >99%ee

    Coumarin; VKORC1 inhibitor.

    ≥99%
  • M4000

    MK-2206 Monohydrochloride

    Akt inhibitor.

    ≥99%
  • D5612

    2-n-Dodecylfuran

    Furan derivative.

    ≥98%
  • R3014

    Recombinant TpN 47 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • C9610

    D-Cycloserine

    NMDA partial agonist, D-Ala-D-Ala ligase inhibi...

    ≥98%
  • C2965

    Chromium Picolinate

    Used to prevent chromium deficiency and to decr...

    ≥98%
  • S7601

    Statil

    Aldose reductase inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only