SCH-772984

Name: SCH-772984
SKU: S0929
Availability: InStock

Product ID S0929

Cas No. 942183-80-4

Purity ≥97%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

SCH-772984 is an inhibitor of ERK1/2 that exhibits anticancer chemotherapeutic activity. This compound inhibits cell and tumor growth in a variety of models, including cells featuring B-Raf, NRAS, and KRAS mutations. In combination with the braf inhibitor vemurafenib, SCH-722984 shows efficacy against BRAF-mutant melanoma with innate or required resistance or non-BRAF mutant melanoma. It also exhibits antitumor efficacy in pancreatic cancer cells when combined with cucurbitacin B, a natural tetracyclic triterpene.

Product Info

Cas No.	942183-80-4
Purity	≥97%
Formula	C₃₃H₃₃N₉O₂
Formula Wt.	587.69
Chemical Name	(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide
IUPAC Name	(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide
Synonym	SCH-772984, SCH772984, SCH 772984
Solubility	DMSO 14 mg/mL warmed (23.82 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	S0929 MSDS PDF
Info Sheet	S0929 Info Sheet PDF

References

Nissan MH, Rosen N, Solit DB. ERK pathway inhibitors: how low should we go? Cancer Discov. 2013 Jul;3(7):719-21. PMID: 23847348.

Morris EJ, Jha S, Restaino CR, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul;3(7):742-50. PMID: 23614898.

Wong D., Robert L, et al. Antitumor activity of the ERK inhibitor SCH772984 [corrected] against BRAF mutant, NRAS mutant and wild-type melanoma. Mol Cancer. 13:194 (2014). PMID: 25142146.

Zhou J., Zhao T., et al. Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling. 8(61):103167-81 (2017). PMID: 29262554.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

SCH-772984

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Kemptide

BAY-1895344

β-Endorphin, human

Hyaluronic Acid Sodium (~1,000,000)

Glucagon-like Peptide II, rat

Cerulenin

KX1-004

Myelin Basic Protein (87-99), guinea pig/human

Intepirdine

Pipemidic Acid

GDC-0941

MLN8237

Arbutin

Incensol Acetate

Kallikrein Inhibitor

Cafestol Acetate

β-Zearalanol

Oxfendazole

R,S-(±)-Sulpiride

Piroxicam

Footer