LKT Labs

Biochemicals for Life Science Research

SCH-772984

Product ID S0929
Cas No. 942183-80-4
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $55.00 In stock
5 mg $150.00 In stock
10 mg $250.00 In stock
25 mg $450.00 In stock
Bulk Quote

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Description

SCH-772984 is an inhibitor of ERK1/2 that exhibits anticancer chemotherapeutic activity. This compound inhibits cell and tumor growth in a variety of models, including cells featuring B-Raf, NRAS, and KRAS mutations. In combination with the braf inhibitor vemurafenib, SCH-722984 shows efficacy against BRAF-mutant melanoma with innate or required resistance or non-BRAF mutant melanoma. It also exhibits antitumor efficacy in pancreatic cancer cells when combined with cucurbitacin B, a natural tetracyclic triterpene.

Product Info

Cas No.

942183-80-4
Purity

≥97%
Formula

C33H33N9O2
Formula Wt.

587.69
Chemical Name

(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide
IUPAC Name

(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide
Synonym

SCH-772984, SCH772984, SCH 772984
Solubility

DMSO 14 mg/mL warmed (23.82 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

S0929 MSDS PDF
Info Sheet

S0929 Info Sheet PDF

References

Nissan MH, Rosen N, Solit DB. ERK pathway inhibitors: how low should we go? Cancer Discov. 2013 Jul;3(7):719-21. PMID: 23847348.

Morris EJ, Jha S, Restaino CR, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul;3(7):742-50. PMID: 23614898.

Wong D., Robert L, et al. Antitumor activity of the ERK inhibitor SCH772984 [corrected] against BRAF mutant, NRAS mutant and wild-type melanoma. Mol Cancer. 13:194 (2014). PMID: 25142146.

Zhou J., Zhao T., et al. Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling. 8(61):103167-81 (2017). PMID: 29262554.

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