LKT Labs

Biochemicals for Life Science Research

SCH-772984

SCH-772984

Product ID S0929
Cas No. 942183-80-4
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $57.80 In stock
5 mg $157.50 In stock
10 mg $262.50 In stock
25 mg $472.50 In stock
Bulk Quote

Quicklinks

Description

SCH-772984 is an inhibitor of ERK1/2 that exhibits anticancer chemotherapeutic activity. This compound inhibits cell and tumor growth in a variety of models, including cells featuring B-Raf, NRAS, and KRAS mutations. In combination with the braf inhibitor vemurafenib, SCH-722984 shows efficacy against BRAF-mutant melanoma with innate or required resistance or non-BRAF mutant melanoma. It also exhibits antitumor efficacy in pancreatic cancer cells when combined with cucurbitacin B, a natural tetracyclic triterpene.

Product Info

Cas No.

942183-80-4
Purity

≥97%
Formula

C33H33N9O2
Formula Wt.

587.69
Chemical Name

(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide
IUPAC Name

(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide
Synonym

SCH-772984, SCH772984, SCH 772984
Solubility

DMSO 14 mg/mL warmed (23.82 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

S0929 MSDS PDF
Info Sheet

S0929 Info Sheet PDF

References

Nissan MH, Rosen N, Solit DB. ERK pathway inhibitors: how low should we go? Cancer Discov. 2013 Jul;3(7):719-21. PMID: 23847348.

Morris EJ, Jha S, Restaino CR, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul;3(7):742-50. PMID: 23614898.

Wong D., Robert L, et al. Antitumor activity of the ERK inhibitor SCH772984 [corrected] against BRAF mutant, NRAS mutant and wild-type melanoma. Mol Cancer. 13:194 (2014). PMID: 25142146.

Zhou J., Zhao T., et al. Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling. 8(61):103167-81 (2017). PMID: 29262554.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L1616

    LEE-011

    CDK4/6 inhibitor.

    ≥98%
  • H0207

    Hepatitis B Virus Core Protein (128-140)

    B cell epitope found on hepatitis B viral core ...

    ≥95%
  • E0003

    E64-d

    Cathepsin inhibitor.

    ≥97%
  • L3551

    Limonin Glucoside

    Furanolactone found in Citrus.

    ≥95%
  • D0011

    Dacarbazine

    DNA alkylator.

    ≥98%
  • B1855

    O6-Benzylguanine

    MGMT inhibitor.

    ≥98%
  • H9618

    Hydroquinone

    Basic phenol skeleton structure found in variou...

    ≥96%
  • C4658

    Clopidogrel Sulfate

    Thienopyridine; P2Y12 antagonist.

    ≥98%
  • I6932

    Irinotecan

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • R0110

    Ractopamine Hydrochloride

    β1/2-adrenergic agonist.

    ≥97%
  • R5661

    Ropinirole Hydrochloride

    Indoline; D2/3 agonist.

    ≥99%
  • M1444

    MDL 29951

    GPR17 agonist, NMDA and fructose 1,6-bisphospha...

    ≥98%
  • H3278

    HIV Reverse Transcriptase A2.1 Peptide

    Peptide, HIV-1 RT A2.1 epitope.

    ≥95%
  • T1672

    Terbinafine Hydrochloride

    Allylamine; squalene oxidase and KSR1 inhibitor...

    ≥98%
  • N8660

    NVP-AUY922

    Isoxazole derivative; HSP90 inhibitor.

    ≥98%
  • A5059

    Amoxapine

    5-HT2/3/6/7, D2/3/4, histamine H1, α1-adrenerg...

    ≥98%
  • A4930

    7-Aminoactinomycin D

    Actinomycin derivative used to study apoptosis ...

    ≥98%
  • I7458

    1-Isothiocyanato-9-(methylsulfinyl)-nonane

    ITC, sulforaphane analog.

    ≥98%
  • D3352

    Dinaciclib

    BRD binding agent, CDK1/2/5/9 inhibitor.

    ≥99%
  • T0103

    Taxol Side Chain Diol

    Side chain attached to various taxanes.

    ≥98%