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SCH-900776

SCH-900776

Product ID S0928
Cas No. 891494-63-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $178.60 Please Inquire
5 mg $355.30 Please Inquire
10 mg $592.50 Please Inquire
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

SCH-900776 is an inhibitor of checkpoint kinase (CHK) 1 that exhibits anticancer chemotherapeutic activity. SCH-900776 is currently in clinical trials as a potential co-administered treatment for cancer. With other chemotherapeutics, SCH-900776 induces double-stranded DNA strand breaks and cell death.

Product Info

Cas No.

891494-63-6

Purity

≥98%

Formula

C15H18BrN7

Formula Wt.

376.25

IUPAC Name

6-bromo-3-(1-methylpyrazol-4-yl)-5-[(3R)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidin-7-amine

Synonym

MK-8776

Solubility

DMSO 3 mg/mL (7.97 mM) Water Insoluble Ethanol Insoluble

Appearance

Pale yellow powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

S0928 MSDS PDF

Info Sheet

S0928 Info Sheet PDF

References

Dai Y, Chen S, Kmieciak M, et al. The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair. Mol Cancer Ther. 2013 Jun;12(6):878-89. PMID: 23536721.

Karp JE, Thomas BM, Greer JM, et al. Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias. Clin Cancer Res. 2012 Dec 15;18(24):6723-31. PMID: 23092873.

Guzi TJ, Paruch K, Dwyer MP, et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602. PMID: 21321066.

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