• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Sitagliptin Phosphate Monohydrate

Sitagliptin Phosphate Monohydrate

Product ID S3476
Cas No. 654671-77-9
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $63.00 In stock
25 mg $89.30 In stock
100 mg $183.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Sitagliptin is an anti-diabetic/anti-hyperglycemic compound that inhibits dipeptidyl peptidase 4 (DPP4); sitagliptin also exhibits antioxidative and cardioprotective benefit. Sitagliptin decreases release of lactate dehydrogenase, malondialdehyde, and creatine kinase MB, and increases levels of glutathione peroxidase, glucagon-like peptide 1 (GLP-1), and superoxide dismutase; this compound also decreases expression of caspases 3 and 9, causing decreases in cardiac apoptosis and improvements in cardiac function. In hypertensive rats, sitagliptin increases levels of GLP-1, the GLP-1 receptor, cAMP, and eNOS and also increases activation of AMPK, improving vascular endothelial function.

Product Info

Cas No.

654671-77-9

Purity

≥98%

Formula

C16H15F6N5O • H3PO4 • H2O

Formula Wt.

523.32

Chemical Name

(3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; phosphoric acid; hydrate

IUPAC Name

(3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4, 3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;phosphoric acid

Synonym

MK-0431

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

S3476 MSDS PDF

Info Sheet

S3476 Info Sheet PDF

References

Chang G, Zhang P, Ye L, et al. Protective effects of sitagliptin on myocardial injury and cardiac function in an ischemia/reperfusion rat model. Eur J Pharmacol. 2013 Oct 15;718(1-3):105-13. PMID: 24041927.

Kubota Y, Miyamoto M, Takagi G, et al. The dipeptidyl peptidase-4 inhibitor sitagliptin improves vascular endothelial function in type 2 diabetes. J Korean Med Sci. 2012 Nov;27(11):1364-70. PMID: 23166419.

Liu L, Liu J, Wong WT, et al. Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension. 2012 Sep;60(3):833-41. PMID: 22868389.

Waget A, Cabou C, Masseboeuf M, et al. Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice. Endocrinology. 2011 Aug;152(8):3018-29. PMID: 21673098.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A0002

    A66

    p110α PI3K inhibitor.

    ≥98%
  • A7658

    Atorvastatin Calcium Trihydrate

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • G5322

    GNF-5

    Abl inhibitor.

    ≥99%
  • C2968

    Chrysin

    Flavone found in Passiflora, Oroxylum, and Pleu...

    ≥98%
  • P0005

    Pituitary Adenylate Cyclase-activating Polypeptide (1-27), human, sheep, rat

    Endogenous peptide, involved in paracrine and a...

    ≥95%
  • G4580

    Glucosamine Hydrochloride

    Endogenous amino sugar precursor required for p...

    ≥96%
  • M2400

    MG-132

    Proteasome inhibitor.

    ≥98%
  • K1653

    Kendomycin

    Macrolide; ET antagonist, proteasome inhibitor....

    ≥98%
  • O2145

    Ofloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • A4000

    AK-1

    SIRT2 inhibitor.

    ≥99%
  • P465822

    Pluripotin

    Dual kinase and GTPase inhibitor.

    ≥98%
  • B1979

    Betulinic Acid

    Pentacyclic triterpene.

    ≥99%
  • P1952

    Penitrem A

    Neuroactive mycotoxin produced by Penicillum an...

    ≥97%
  • C0140

    Calcitonin, eel

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • T1672

    Terbinafine Hydrochloride

    Allylamine; squalene oxidase and KSR1 inhibitor...

    ≥98%
  • D004098

    Dacomitinib Anhydrous

    EGFR inhibitor.

    ≥99%
  • S1059

    Scopolamine Hydrobromide Trihydrate

    Tropane alkaloid found in Solanaceae plants; M1...

    ≥98%
  • O451328

    Oligomycin C

    Macrocyclic lactone.

    ≥97%
  • V3213

    Vidarabine Monophosphate

    Nucleoside (adenosine) analog found in Tethyra ...

    ≥98.0%
  • V1870

    Verruculogen

    Mycotoxin produced by Aspergillus; BK K+ channe...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only