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Spironolactone is a diuretic that inhibits aldosterone receptors, mineralocorticoid receptors, androgen receptors, and endothelial Na+ channels (ENaCs). Spironolactone exhibits antihypertensive activity and is clinically used to treat heart failure. Spironolactone may inhibit voltage-gated Ca2+ channels.
| Cas No. | 52-01-7 |
|---|---|
| Purity | ≥97% |
| Formula | C24H32O4S |
| Formula Wt. | 416.57 |
| Chemical Name | (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4- ene-21-carboxylic acid γ-lactone |
| IUPAC Name | S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9, 11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17, 2'-oxolane]-7-yl] ethanethioate |
| Synonym | Spirolactone, Spiroctan, Aldactone |
| Melting Point | 134-135°C (lit.) |
| Solubility | Soluble in organic solvents. Practically insoluble in water. |
| Appearance | Off-White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013 Oct 15;62(16):e147-239. PMID: 23747642.
Mann SJ, Parikh NS. A simplified mechanistic algorithm for treating resistant hypertension: efficacy in a retrospective study. J Clin Hypertens (Greenwich). 2012 Apr;14(4):191-7. PMID: 22458739.
Nappi JM, Sieg A. Aldosterone and aldosterone receptor antagonists in patients with chronic heart failure. Vasc Health Risk Manag. 2011;7:353-63. PMID: 21731887.