• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
S,S-(+)-Tetrandrine

S,S-(+)-Tetrandrine

Product ID T1777
Cas No. 518-34-3
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $86.80 In stock
500 mg $236.50 In stock
1 g $364.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

S,S-Tetrandrine is a benzylisoquinoline alkaloid originally found in Stephania that exhibits anti-inflammatory, anti-allergic, analgesic, neuroprotective, cognition enhancing, anti-depressant, anti-osteoporotic, antiviral, and anticancer chemotherapeutic activities. Tetrandrine is a Ca2+ channel blocker; it inhibits mast cell degranulation and suppresses LPS-stimulated expression of COX and inflammatory cytokines, preventing hyperalgesia in animal models. Tetrandrine also inhibits neurological deficits, decreases infarct size, and suppresses brain edema in animal models of cerebral ischemia/reperfusion. Similarly, this compound inhibits amyloid-β (Aβ)-induced memory and learning impairments in animal models of Alzheimer’s disease. In cellular and animal models of osteoporosis, tetrandrine inhibits osteoclast differentiation and prevents decrease in bone mass. This compound decreases immobility time in the forced swim test and tail suspension test and increases levels of BDNF, 5-HT, and NE in the hippocampus of animal models. In gallbladder carcinoma cells, tetrandrine induces S phase cell cycle arrest, alters the Bcl-2/Bax ratio, induces apoptosis, and inhibits proliferation. Additionally, this compound induces regression in animal models of chromic myelogenous leukemia (CML), decreasing levels of Bcr-Abl and β-catenin. Tetrandrine also prevents Ebola virus infection in animal models.

Product Info

Cas No.

518-34-3

Purity

≥98%

Formula

C38H42N2O6

Formula Wt.

622.75

Chemical Name

(1β)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman

IUPAC Name

(1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene

Melting Point

217-218°C

Solubility

Soluble in ether. Practically insoluble in water.

Appearance

White crystal powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T1777 MSDS PDF

Info Sheet

T1777 Info Sheet PDF

Brochures

WNT Booklet

References

Sakurai Y, Kolokoltsov AA, Chen CC, et al. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science. 2015 Feb 27;347:995-998.

Zhu R, Liu T, Tan Z, et al. Tetrandrine induces apoptosis in gallbladder carcinoma in vitro. Int J Clin Pharmacol Ther. 2014 Jul 30. [Epub ahead of print]. PMID: 25074868.

Zhao H, Luo F, Li H, et al. Antinociceptive effect of tetrandrine on LPS-induced hyperalgesia via the inhibition of IKKβ phosphorylation and the COX-2/PGE₂ pathway in mice. PLoS One. 2014 Apr 10;9(4):e94586. PMID: 24722146.

Ruan L, Huang HS, Jin WX, et al. Tetrandrine attenuated cerebral ischemia/reperfusion injury and induced differential proteomic changes in a MCAO mice model using 2-D DIGE. Neurochem Res. 2013 Sep;38(9):1871-9. PMID: 23780673.

Gao S, Cui YL, Yu CQ, et al. Tetrandrine exerts antidepressant-like effects in animal models: role of brain-derived neurotrophic factor. Behav Brain Res. 2013 Feb 1;238:79-85. PMID: 23085478.

Xu XH, Gan YC, Xu GB, et al. Tetrandrine citrate eliminates imatinib-resistant chronic myeloid leukemia cells in vitro and in vivo by inhibiting Bcr-Abl/β-catenin axis. J Zhejiang Univ Sci B. 2012 Nov;13(11):867-74. PMID: 23125079.

Takahashi T, Tonami Y, Tachibana M, et al. Tetrandrine prevents bone loss in sciatic-neurectomized mice and inhibits receptor activator of nuclear factor κB ligand-induced osteoclast differentiation. Biol Pharm Bull. 2012;35(10):1765-74. PMID: 23037166.

He FQ, Qiu BY, Zhang XH, et al. Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer's disease induced by amyloid-β(1-42). Brain Res. 2011 Apr 12;1384:89-96. PMID: 21300035.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E5220

    Enfuvirtide (T-20)

    Synthetic peptide derived from HIV-1; viral fus...

    ≥95%
  • B3272

    Bis(3,5-dibromosalicyl) Fumarate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥91%
  • C9662

    Cyproterone Acetate

    Steroid; AR antagonist.

    ≥98%
  • V0145

    Valinomycin

    Peptide, neutral ionophore.

    ≥98%
  • L0360

    Lapatinib Ditosylate Monohydrate

    EGFR inhibitor.

    ≥99%
  • N7332

    NSI-189

    Stem cell neurogenesis inducer.

    ≥99%
  • S7871

    Stresscopin, human

    Peptide, urocortin III analog; CRFR2 agonist.

    ≥95%
  • A4534

    Aliskiren Hemifumarate

    Renin inhibitor.

    ≥98%
  • C4656

    Clopidol

    Coccidiostat.

    ≥98%
  • I7658

    1-Isothiocyanato-9-(methylsulfonyl)-nonane

    Synthetic ITC, erysolin analog.

    ≥98%
  • S3453

    Sinigrin Monohydrate, synthetic

    ITC precursor found in cruciferous vegetables.<...

    ≥98%
  • D1720

    Deferiprone

    Iron chelator.

    ≥99%
  • C1613

    Cediranib

    VEGFR inhibitor.

    ≥98%
  • L0249

    Laminin Peptide YIGSR-NH2

    Laminin-derived peptapeptide.

    ≥98%
  • R2810

    Recombinant Multi-epitope Chimeric HIV Antigen 1

    Recombinant HIV-1 multi-epitope chimeric antige...

    ≥95%
  • A064766

    ABT 639

    T-type calcium channel blocker

    ≥99%
  • T5609

    β-Tocotrienol

    Antioxidant, vitamin E derivative found in vege...

    ≥98%
  • D1774

    Desloratadine

    Loratadine metabolite; FIASMA, histamine H1 ant...

    ≥97%
  • P3561

    Piperlongumine

    Found in Piper longum; TxA2 antagonist, ubiquit...

    ≥98%
  • N1858

    Neosolaniol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only