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StemRegenin 1 Hydrochloride

StemRegenin 1 Hydrochloride

Product ID S7618
Cas No. 2319882-01-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $109.80 In stock
25 mg $396.90 In stock
50 mg $616.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

StemRegenin is an immunostimulatory antagonist at the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases dendritic cell production, allogenic T cell responses, and IFN-α, TNF-α, and IL-12 expression. In combination with BMP4 and PGE2, stemRegenin 1 induces differentiation and expression of inducible pluripotent stem cells (iPSCs).

Product Info

Cas No.

2319882-01-2

Purity

≥98%

Formula

C24H23N5OS • HCl

Formula Wt.

466.00

IUPAC Name

4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol;hydrochloride

Synonym

SR1

Solubility

DMSO: ≥ 33 mg/mL

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S7618 MSDS PDF

Info Sheet

S7618 Info Sheet PDF

References

Thordardottir S, Hangalapura BN, Hutten T, et al. The aryl hydrocarbon receptor antagonist StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells. Stem Cells Dev. 2014 May 1;23(9):955-67. PMID: 24325394.

Gori JL, Chandrasekaran D, Kowalski JP, et al. Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells. Blood. 2012 Sep 27;120(13):e35-44. PMID: 22898598.

Boitano AE, Wang J, Romeo R, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010 Sep 10;329(5997):1345-8. Erratum in: Science. 2011 May 6;332(6030):664. PMID: 20688981.

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