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StemRegenin is an immunostimulatory antagonist at the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases dendritic cell production, allogenic T cell responses, and IFN-α, TNF-α, and IL-12 expression. In combination with BMP4 and PGE2, stemRegenin 1 induces differentiation and expression of inducible pluripotent stem cells (iPSCs).
| Cas No. | 2319882-01-2 |
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| Purity | ≥98% |
| Formula | C24H23N5OS • HCl |
| Formula Wt. | 466.00 |
| IUPAC Name | 4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol;hydrochloride |
| Synonym | SR1 |
| Solubility | DMSO: ≥ 33 mg/mL |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Thordardottir S, Hangalapura BN, Hutten T, et al. The aryl hydrocarbon receptor antagonist StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells. Stem Cells Dev. 2014 May 1;23(9):955-67. PMID: 24325394.
Gori JL, Chandrasekaran D, Kowalski JP, et al. Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells. Blood. 2012 Sep 27;120(13):e35-44. PMID: 22898598.
Boitano AE, Wang J, Romeo R, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010 Sep 10;329(5997):1345-8. Erratum in: Science. 2011 May 6;332(6030):664. PMID: 20688981.