Description
STING Agonist-12 is an activator of STING.
Product Unit Size | Cost | Quantity | Stock |
---|
STING Agonist-12 is an activator of STING.
Cas No. | 2259624-71-8 |
---|---|
Purity | ≥99% |
Formula | C25H19ClF4N2O2 |
Formula Wt. | 490.88 |
IUPAC Name | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]indole-6-carboxamide |
Synonym | Compound 53, STING Agonist C53, GTPL11960 |
Appearance | White powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Pryde D, Middya S, Banerjee M, et al. The discovery of potent small molecule activators of human STING. Eur J Med Chem. 2021 Jan 1;209:112869. PMID: 33038794
Lu D, Shang G, Li J, et al. Activation of STING by targeting a pocket in the transmembrane domain. Nature. 2022 Apr;604(7906):557-562. PMID: 35388221
Steroid; glucocorticoid agonist.
Proteasome inhibitor.
Macrolide lactone antibiotic.
Regioisomers
Purine nucleoside analog; DNA chain terminator,...
Diterpene found in Anisomeles.
BHA derivative, antioxidative food and cosmetic...
Modified nucleotide used for labeling DNA; DNA ...
Salicylic acid prodrug, NSAID; weak COX-1/2 inh...
JAK2 inhibitor.
Endogenous peptide hormone, involved in water h...
GABA-A agonist.
Flavonoid found in Scutellaria; CDK9 inhibitor....
BRD2/4/9 and CECR2 inhibitor.
VEGFR inhibitor.
MGMT inhibitor.
GABA analog; GABA potentiator, adenosine A1 ago...
Endogenous neuropeptide, involved in energy hom...
ERK1/2 inhibitor.
mTOR activator.