• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Substance P (7-11)

Substance P (7-11)

Product ID S8009
Cas No. 51165-05-0
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $81.70 In stock
2 mg $138.90 In stock
5 mg $245.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Substance P (SP) is an endogenous tachykinin neuropeptide that is involved in inflammatory, pain, and stress signaling; it exhibits neuroprotective, cognition enhancing, and gastrointestinal motility modulating activities. SP exhibits neuroprotective activity by decreasing expression of Kv1.4 K+ channels in transgenic animal models of Alzheimer’s disease and improving cognitive performance in the Morris water maze task. SP is the natural ligand for the neurokinin-1 (NK1) receptor. In various animal models, SP modulates opioid signaling, induces gastric mucosal protection, and inhibits retinal apoptosis. SP also prevents hyperoxia-induced lung damage, decreasing levels of malondialdehyde and increasing levels of superoxide dismutase (SOD); this activity may be regulated through SHH signaling. In melanoma cells, SP decreases levels of tyrosinase and melanin, inhibiting melanogenesis. In other cellular models, SP increases the viability and proliferation of osteoblasts and promotes gap junction intracellular communication.

Product Info

Cas No.

51165-05-0

Purity

≥95%

Formula

C31H44N6O5S

Formula Wt.

612.8

IUPAC Name

N-(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)-2-[[2-[[2-[(2-amino-3-phenylpropanoyl)amino]-3-phenylpropanoyl]amino]acetyl]amino]-4-methylpentanamide

Solubility

Soluble in water.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S8009 MSDS PDF

Info Sheet

S8009 Info Sheet PDF

References

Yang L, Liu C, Dang H, et al. Substance P attenuates hyperoxia induced lung injury in neonatal rats. Mol Med Rep. 2014 Feb;9(2):595-9. PMID: 24247295.

Campolongo P, Ratano P, Ciotti MT, et al. Systemic administration of substance P recovers beta amyloid-induced cognitive deficits in rat: involvement of Kv potassium channels. PLoS One. 2013 Nov 12;8(11):e78036. PMID: 24265678.

Yang JH, Guo Z, Zhang T, et al. Restoration of endogenous substance P is associated with inhibition of apoptosis of retinal cells in diabetic rats. Regul Pept. 2013 Nov 10;187:12-6. PMID: 24045094.

Ma W, Zhang X, Shi S, et al. Neuropeptides stimulate human osteoblast activity and promote gap junctional intercellular communication. Neuropeptides. 2013 Jun;47(3):179-86. PMID: 23726661.

Brancati SB, Zádori ZS, Németh J, et al. Substance P induces gastric mucosal protection at supraspinal level via increasing the level of endomorphin-2 in rats. Brain Res Bull. 2013 Feb;91:38-45. PMID: 23328537.

Ping F, Shang J, Zhou J, et al. Activation of neurokinin-1 receptor by substance P inhibits melanogenesis in B16-F10 melanoma cells. Int J Biochem Cell Biol. 2012 Dec;44(12):2342-8. PMID: 23041339.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S8144

    Sulfadoxine

    Sulfonamide; dihydropteroate synthase inhibitor...

    ≥98%
  • I4934

    Imipenem Monohydrate

    Carbapenem β-lactam; penicillin binding protei...

    ≥98%
  • I7447

    1-Isothiocyanato-6-(methylsulfenyl)-hexane

    Synthetic ITC, erucin analog.

    ≥98%
  • M1605

    Mebendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • N3310

    Nicotinamide

    Amide form of vitamin B3 required for productio...

    ≥98%
  • T1004

    Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity

    Synthesis impurity

    ≥92%
  • C0245

    Calcitonin Gene Related Peptide, rat

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • G0146

    Galanin, human

    Endogenous neuropeptide, involved in nociceptio...

    ≥98%
  • Z0944

    ZCL-278

    Cdc42 inhibitor.

    ≥98%
  • O9398

    Oxymetazoline Hydrochloride

    Imidazoline derivative; α1-adrenergic agonist,...

    ≥98%
  • P1869

    Perindopril Erbumine

    ACE inhibitor.

    ≥95%
  • L283080

    LHC-165

    TLR7 agonist

    ≥99%
  • C5864

    Coptisine Chloride, synthetic

    Isoquinoline alkaloid found in a variety of pla...

    ≥98%
  • A4854

    β-Amyloid Peptide (1-42), rat

    Endogenous APP peptide cleavage product, primar...

    ≥95%
  • C9677

    Cyclocytidine Hydrochloride

    Pyrimidine nucleoside analog; DNA synthesis inh...

    ≥98%
  • K1653

    Kendomycin

    Macrolide; ET antagonist, proteasome inhibitor....

    ≥98%
  • T5060

    TMP-269

    HDAC inhibitor.

    ≥98%
  • C1613

    Cediranib

    VEGFR inhibitor.

    ≥98%
  • T0205

    3”,4”-Dehydropaclitaxel C

    Semi-synthetic taxane.

    ≥95%
  • C9882

    Cytochalasin E

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only