• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Sunitinib Malate

Sunitinib Malate

Product ID S8253
Cas No. 341031-54-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $78.10 In stock
25 mg $204.30 In stock
100 mg $638.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Sunitinib is an inhibitor of several tyrosine kinases, including PDGFR, VEGFR, KIT, and FLT3. Sunitinib also inhibits mTORC1 signaling. Sunitinib is currently clinically used to treat renal cell carcinoma and gastrointestinal stromal tumors, but is in clinical trials as a potential treatment for a variety of other cancers. Sunitinib exhibits anticancer chemotherapeutic, anti-angiogenic, and anti-fibrotic activities. In anaplastic thyroid cancer cells, sunitinib decreases activity of VEGFR2, prevents phosphorylation of EGFR, ERK1/2, and Akt, and suppresses expression of cyclin D1, inhibiting cell proliferation; in paired animal models, this compound inhibits tumor growth. In acute myelogenous leukemia (AML) cells, sunitinib decreases expression of cyclin D1, cyclin D3, cyclin-dependent kinase 2 (CDK2), Bcl-2, and Mcl-1 and increases expression of p27, pRb1, p130, Bax, Bak, Fas, FasL, DR4, DR5, and activated PKC, resulting in activation of caspases 2, 3, 8, and 9 and apoptosis. In endothelial cells, sunitinib inhibits tube formation and vascular sprouting. In animal models, sunitinib decreases cyst area and increases the number of cyst-free subjects, indicating potential benefit in the treatment of endometriosis. Additionally, this compound inhibits collagen synthesis, cell migration, contraction, and cell differentiation of hepatic stellate cells.

Product Info

Cas No.

341031-54-7

Purity

≥98%

Formula

C26H33FN4O7

Formula Wt.

532.56

IUPAC Name

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene) methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid

Synonym

Sutent

Melting Point

194-200°C

Solubility

Soluble in DMSO at 40 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility

Appearance

Brown to Orange Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

S8253 MSDS PDF

Info Sheet

S8253 Info Sheet PDF

References

Tran TA, Kinch L, Peña-Llopis S, et al. Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1. Mol Cell Biol. 2013 Oct;33(19):3762-79. PMID: 23878397.

Di Desidero T, Fioravanti A, Orlandi P, et al. Antiproliferative and proapoptotic activity of sunitinib on endothelial and anaplastic thyroid cancer cells via inhibition of Akt and ERK1/2 phosphorylation and by down-regulation of cyclin-D1. J Clin Endocrinol Metab. 2013 Sep;98(9):E1465-73. PMID: 23969186.

Abbas MA, Disi AM, Taha MO. Sunitinib as an anti-endometriotic agent. Eur J Pharm Sci. 2013 Jul 16;49(4):732-6. PMID: 23747661.

Majumder S, Piguet AC, Dufour JF, et al. Study of the cellular mechanism of Sunitinib mediated inactivation of activated hepatic stellate cells and its implications in angiogenesis. Eur J Pharmacol. 2013 Apr 5;705(1-3):86-95. PMID: 23454556.

Teng CL, Yu CT, Hwang WL, et al. Effector mechanisms of sunitinib-induced G1 cell cycle arrest, differentiation, and apoptosis in human acute myeloid leukaemia HL60 and KG-1 cells. Ann Hematol. 2013 Mar;92(3):301-13. PMID: 23180436.

George S. Sunitinib, a multitargeted tyrosine kinase inhibitor, in the management of gastrointestinal stromal tumor. Curr Oncol Rep. 2007 Jul;9(4):323-7. PMID: 17588358.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A7034

    Aripiprazole

    D2 and 5-HT1A partial agonist, 5-HT2C/6/7 antag...

    ≥98%
  • G4518

    Glucaric Acid Calcium Tetrahydrate

    Oxidized non-cylic hexose sugar.

    ≥98%
  • D5611

    Docosahexaenoic Acid (all cis-4,7,10,13,16,19) Methyl Ester

    Essential fatty acid found in fish oil, involve...

    ≥99%
  • E7758

    Etomidate

    GABA-A agonist.

    ≥99%
  • G4479

    Glucagon (19-29), human

    Endogenous peptide hormone, glugagon fragment; ...

    ≥95%
  • E4418

    β-Elemene

    Sesquiterpene found in various plant sources. <...

    ≥98%
  • B0109

    Bakuchiol

    Prenylated phenolic terpene found in various pl...

    ≥98%
  • V7200

    VS-5584

    PI3K inhibitor.

    ≥98%
  • T1030

    N-Des-2-methylpropan-2-ol Docetaxel

    N-Des-2-methylpropan-2-ol Docetaxel is an impur...

    ≥90%
  • T1014

    7-TES-Paclitaxel

    Synthesis impurity

    ≥95%
  • T2934

    Thiamphenicol Palmitate

    Chloramphenicol derivative; protein translation...

    ≥98%
  • D3429

    Dihydrocytochalasin B

    Mycotoxin derivative; actin polymerization inhi...

    ≥98%
  • P3592

    Pixantrone Dimaleate

    Aza-anthracenedione, DNA intercalator; topoisom...

    ≥98%
  • T2933

    4-Thiouridine

    Modified nucleotide used for labeling DNA; DNA ...

    ≥99%
  • M0125

    Magnolol

    Lignan found in Magnolia; GABA-A potentiator.

    ≥98%
  • C0351

    Carprofen

    NSAID; COX-2 inhibitor.

    ≥98%
  • V344761

    Vitamin K2

    2-methyl-1,4-naphthoquinone derivative

    ≥98%
  • B6918

    Brevetoxin 3

    Polyether neurotoxin found in Karenia brevis; N...

    ≥95%
  • E5216

    β-Endorphin, camel

    Endogenous opioid peptide; μOR agonist.

    ≥95%
  • R2714

    Recombinant HCV-NS5 Antigens

    Recombinant HCV antigen fragment.

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only