• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
TAE-226

TAE-226

Product ID T0216
Cas No. 761437-28-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.70 In stock
5 mg $248.10 In stock
25 mg $865.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

TAE-226 is an inhibitor of focal adhesion kinase (FAK) that exhibits anti-angiogenic and anticancer activities. In vitro, this compound inhibits angiogenesis, decreases the viability of cancer cells, and suppresses generation of thromboxane A2 (TxA2).

Product Info

Cas No.

761437-28-9

Purity

≥98%

Formula

C23H25ClN6O3

Formula Wt.

468.94

Chemical Name

2-({5-Chloro-2-[(2-Methoxy-4-Morpholin-4-Ylphenyl)amino]pyrimidin-4-Yl}amino)-N-Methylbenzamide

IUPAC Name

2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]-N-methylbenzamide

Synonym

NVP-TAE226

Solubility

DMSO 94 mg/mL Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T0216 MSDS PDF

Info Sheet

T0216 Info Sheet PDF

References

Dao P, Jarray R, Le Coq J, et al. Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4552-6. PMID: 23845217.

Golubovskaya VM, Ho B, Zheng M, et al. Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities. Anticancer Agents Med Chem. 2013 May;13(4):546-54. PMID: 22292772.

Bhavaraju K, Lakhani PR, Dorsam RT, et al. G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets. PLoS One. 2011 Feb 10;6(2):e16586. PMID: 21347357.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E7858

    Etoricoxib

    NSAID; COX-2 inhibitor.

    ≥99%
  • C4559

    Clomiphene Citrate

    Used for in vitro fertilization; FIASMA, SERM.<...

    ≥98%
  • C2951

    Chlortetracycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥85%
  • N5072

    NMS-1286937

    PLK1 inhibitor.

    ≥98%
  • A9617

    Azelnidipine

    Dihydropyridine; L-type Ca2+ channel blocker. &...
    ≥98%
  • F8270

    Furosemide

    Loop diuretic; NKCC symporter inhibitor, CFTR C...

    ≥97%
  • N1769

    Nerolidol, synthetic

    AChE inhibitor, F0F1-ATP synthase modulator.

    A mixture of cis and trans isomers, ≥96%
  • S0929

    SCH-772984

    ERK1/2 inhibitor.

    ≥97%
  • P9767

    Pyriproxyfen

    Juvenile insect hormone mimic.

    ≥95%
  • A4440

    Allicin

    Organosulfur found in garlic, binds DNA; inward...

    ≥98%
  • P327212

    Pifithrin-α-cyclic Hydrobromide

    p53 inhibitor

    ≥98%
  • F5870

    N-formyl-Met-Leu-Phe

    Peptide, involved in neutrophil activation; FPR...

    ≥95%
  • V9200

    VX-950

    NS3/4A serine protease inhibitor.

    ≥98%
  • L5658

    Lonidamine

    Hexokinase inhibitor, aerobic glycolysis inhibi...

    ≥98%
  • U6873

    Ursodeoxycholic Acid

    Endogenous secondary bile acid.

    ≥98%
  • A985130

    AZD-7762

    CHK1 inhibitor.

    ≥98%
  • B3345

    (−)-Bilobalide

    Sesquiterpene lactone found in Ginkgo; GABA-A a...

    ≥98%
  • C4658

    Clopidogrel Sulfate

    Thienopyridine; P2Y12 antagonist.

    ≥98%
  • P200000

    PF-3845

    FAAH inhibitor.

    ≥98%
  • H0003

    H89

    PKA inhibitor, potential ROCK, S6K1, MSK1, PKB ...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only